DOTA-NHS-ester
化学名称
2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
DOTA-NHS-ester•ADC linker
Structure: 
产品编号
CH53020
CAS
170908-81-3
分子式
C20H31N5O10
分子量
501.49
规格标准
| Catalog No. | CH53020 |
| CAS No. | 170908-81-3 |
| Molecular Formula | C20H31N5O10 |
| Molecular Weight | 501.49 |
品类工艺支持
CHEMOS supports ADC linker and bioconjugation building-block projects from route design through custom synthesis and process optimization. Custom linker synthesis : peptide, PEG, self-immolative, cleavable, and non-cleavable linker structures. Functional-handle installation : NHS ester, maleimide, azide, alkyne, and other conjugation-ready groups. Multi-step route development : protecting-group strategy, coupling optimization, purification review, and impurity-profile control. Analytical support : HPLC, NMR, MS, and chiral methods where applicable. Scale-up planning : laboratory-to-production transfer can be evaluated after route feasibility and specification review.
概况
DOTA-NHS-ester (also known as 2-[4,10-bis(carboxymethyl)-7-[2-(2,5-dioxopyrrolidin-1-yl)oxy-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid) (CAS 170908-81-3, MF C20H31N5O10, MW 501.49) belongs to the ADC linker / bioconjugation handle class. Practical chemistry questions involve the conjugation chemistry, peptide-cleavable element design (where applicable), and analytical control of related impurities. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.
应用
- DOTA-NHS-ester (CAS 170908-81-3) preparation, route refinement, and analytical-control planning
- Cleavable peptide-linker design and intracellular-release studies
- Click-chemistry coupling (DBCO / azide) for bioconjugation programs
- Custom linker / payload-linker synthesis on request