2'-O-Methyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C11H15N5O4
- 분자량
- 281.27
- 순도
- >98.0% (HPLC, titration)
2'-O-Methyladenosine (2'-OMe-A, Am) is adenosine with a 2'-O-methyl group on the ribose. CH64020 is identified by CAS 2140-79-6, molecular formula C11H15N5O4, molecular weight 281.27, and PubChem CID 102213.
The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while natural 2'-O-methylation is treated as an RNA-modification reference.
동의어
2'-O-Methyladenosine; 2'-OMe-A; Am
식별 정보 및 규격
| Catalog No. | CH64020 |
| CAS No. | 2140-79-6 |
| Molecular Formula | C11H15N5O4 |
| Molecular Weight | 281.27 |
| PubChem CID | 102213 |
| InChIKey | FPUGCISOLXNPPC-IOSLPCCCSA-N |
| Purity | >98.0% (HPLC, titration) |
보관 조건
Frozen below 0 C
기술 속성
- Nucleobase
- Adenine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-Methyl
- Nucleoside class
- Modified purine ribonucleoside
- Packaging
- 1 g glass bottle with plastic insert; Custom packaging on request
- Physical form
- Solid; white to almost white powder to crystal
- Stability
- >=4 years
응용 맥락
- Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
- RNA-modification reference: 2'-O-methylation occurs naturally in RNA, making CH64020 relevant to tRNA/rRNA modification research.
- 2'-OMe ribonucleoside reference: CH64020 provides the 2'-O-methyladenosine identity for nucleoside chemistry comparisons.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 102213
PubChem · CID 102213
자주 묻는 질문
What does the 2'-O-methyl group do?
A 2'-O-methyl group on the ribose is associated with higher nuclease resistance while retaining RNA-binding affinity, so it is commonly studied in antisense and siRNA oligonucleotide research.
Is 2'-O-methyladenosine a natural RNA modification?
Yes. 2'-O-methylation (for example Am / Gm34) occurs naturally in tRNA and rRNA, so 2'-O-methyladenosine is also a reference in RNA-modification research.
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