7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C16H16F3N5O4
- 분자량
- 399.32
- 순도
- >=98%
7-TFA-ap-7-Deaza-2',3'-dideoxyguanosine is a 2',3'-dideoxy 7-deazaguanosine that carries a 3-(trifluoroacetamido)prop-1-ynyl amino-linker at the C7 position. CH64049 is identified by CAS 114748-68-4, molecular formula C16H16F3N5O4, molecular weight 399.32, PubChem CID 135577907, and InChIKey GMTOEMNRUPBIFY-VHSXEESVSA-N.
The trifluoroacetyl (TFA) group protects a primary amine on the aminopropynyl linker, while the 2',3'-dideoxy sugar defines the chain-terminating nucleoside identity. The cited literature discusses amine-linker nucleosides and 7-deazapurine C7 functionalization in fluorescent labeling and DNA-sequencing research.
동의어
7-(3-trifluoroacetamidoprop-1-ynyl)-7-deaza-2',3'-dideoxyguanosine; 7-TFA-ap-c7-ddG
식별 정보 및 규격
| Catalog No. | CH64049 |
| CAS No. | 114748-68-4 |
| Molecular Formula | C16H16F3N5O4 |
| Molecular Weight | 399.32 |
| PubChem CID | 135577907 |
| InChIKey | GMTOEMNRUPBIFY-VHSXEESVSA-N |
| Purity | >=98% |
보관 조건
-20 C as powder; -80 C in solvent
기술 속성
- Nucleobase analog
- 7-Deazaguanine
- Sugar
- 2',3'-Dideoxyribose
- C7 linker
- 3-Aminoprop-1-ynyl
- Amine protection
- Trifluoroacetyl (TFA)
- Packaging
- 100 mg; 500 mg; Custom packaging on request
- Physical form
- Powder
- Stability
- 3 years as powder; 1 year in solvent
응용 맥락
- Labeled terminator research: CH64049 combines a 2',3'-dideoxy nucleoside identity with a C7 aminopropynyl linker for DNA-sequencing and labeling studies.
- Amine-linker labeling studies: the TFA-protected aminopropynyl group represents a protected amine-linker motif discussed for covalent fluorophore attachment after deprotection.
- Base-analog reference: CH64049 provides the 7-TFA-ap-7-deaza-2',3'-dideoxyguanosine identity for nucleoside chemistry research.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 135577907
PubChem · CID 135577907
자주 묻는 질문
What do 'TFA' and 'ap' mean in the name?
'ap' is the aminopropynyl (3-aminoprop-1-ynyl) linker at C7, and 'TFA' is the trifluoroacetyl group protecting that linker's primary amine.
Why is it a chain terminator?
It is a 2',3'-dideoxynucleoside, which is the sugar pattern associated with chain-terminator designs in DNA-sequencing research. CH64049 also carries a protected C7 amino-linker.
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