2'-O-MOE-N4-Benzoylcytidine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C19H23N3O7
- 분자량
- 405.40
- 순도
- >=98%
2'-O-MOE-N4-Benzoylcytidine is 2'-O-(2-methoxyethyl)cytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64096 is identified by CAS 2305416-18-4, molecular formula C19H23N3O7, molecular weight 405.40, PubChem CID 168449060, and InChIKey VDTLYOJAWYZWEE-GFOCRRMGSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
동의어
2'-O-MOE-N4-Benzoylcytidine; 2'-O-(2-methoxyethyl)-N4-benzoylcytidine; MOE-rC(Bz)
식별 정보 및 규격
| Catalog No. | CH64096 |
| CAS No. | 2305416-18-4 |
| Molecular Formula | C19H23N3O7 |
| Molecular Weight | 405.40 |
| PubChem CID | 168449060 |
| InChIKey | VDTLYOJAWYZWEE-GFOCRRMGSA-N |
| Purity | >=98% |
보관 조건
2-8 C
기술 속성
- Nucleobase
- Cytosine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N4-Benzoyl
- Synthesis role
- Base-protected MOE nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
응용 맥락
- Base-protected 2'-O-MOE building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
- Nucleoside chemistry identity: a defined 2'-O-MOE-N4-benzoylcytidine compound for nucleoside chemistry research.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 168449060
PubChem · CID 168449060
자주 묻는 질문
How does it differ from N4-benzoyl-2'-O-methylcytidine?
Both are N4-benzoyl base-protected cytidines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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