5'-O-DMT-2'-O-MOE-5-methyluridine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C34H38N2O9
- 분자량
- 618.7
- 순도
- 99%
5'-O-DMT-2'-O-MOE-5-methyluridine is 2'-O-(2-methoxyethyl)-5-methyluridine (its base is 5-methyluracil) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64129 is identified by CAS 163759-50-0, molecular formula C34H38N2O9, molecular weight 618.7, PubChem CID 15864049, and InChIKey WIPCVBQXKBWNRC-PBAMLIMUSA-N.
It is a 2'-O-MOE-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. Because the 5-methyluracil base has no exocyclic amine, no base protecting group is required.
동의어
5'-O-DMT-2'-O-MOE-5-methyluridine; DMT-2'-MOE-5Me-rU
식별 정보 및 규격
| Catalog No. | CH64129 |
| CAS No. | 163759-50-0 |
| Molecular Formula | C34H38N2O9 |
| Molecular Weight | 618.7 |
| PubChem CID | 15864049 |
| InChIKey | WIPCVBQXKBWNRC-PBAMLIMUSA-N |
| Purity | 99% |
보관 조건
2-8 C
기술 속성
- Nucleobase
- 5-Methyluracil
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- Unprotected
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 100 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white to off-white powder
응용 맥락
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies.
- No base protection needed: the 5-methyluracil base has no exocyclic amine, so this building block requires no base protecting group.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 15864049
PubChem · CID 15864049
자주 묻는 질문
How does it differ from 5'-O-DMT-5-methyl-2'-O-methyluridine?
Both are 5'-O-DMT-protected 5-methyluridines, but this one has a 2'-O-methoxyethyl (2'-MOE) modification, whereas the other has a 2'-O-methyl modification. The 2'-OMe form is cataloged separately.
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