2'-O-MOE-Guanosine (iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C47H60N7O10P
- 분자량
- 914.0
- 순도
- >=99% (HPLC)
2'-O-MOE-Guanosine (iBu) CE Phosphoramidite is the 2'-O-methoxyethyl guanosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65034 is identified by CAS 251647-55-9, molecular formula C47H60N7O10P, molecular weight 914.0, PubChem CID 136745830, and InChIKey LADCDGNEBIQAAU-SBCRAQIVSA-N.
Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
동의어
DMT-2'-O-MOE-rG(iBu) phosphoramidite; 5'-O-DMT-2'-O-MOE-N2-isobutyrylguanosine 3'-CE phosphoramidite
식별 정보 및 규격
| Catalog No. | CH65034 |
| CAS No. | 251647-55-9 |
| Molecular Formula | C47H60N7O10P |
| Molecular Weight | 914.0 |
| PubChem CID | 136745830 |
| InChIKey | LADCDGNEBIQAAU-SBCRAQIVSA-N |
| Purity | >=99% (HPLC) |
보관 조건
-20 C
기술 속성
- Monomer class
- 2'-O-MOE RNA CE phosphoramidite
- Nucleobase
- Guanine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N2-Isobutyryl
- Grade
- TheraPure
- Packaging
- 50 mg; 200 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g; 200 g; Custom packaging on request
- Water content
- <=0.3% by KF
- Physical form
- white to off-white powder
- Stability
- powder: 3 years at -20 C
응용 맥락
- 2'-MOE RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies and as gapmer flank residues.
- 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 136745830
PubChem · CID 136745830
자주 묻는 질문
What does this 2'-MOE amidite do in RNA synthesis?
Its 3'-phosphoramidite couples to the growing chain, with 5'-DMT removed each cycle and N2-isobutyryl removed at final deprotection. The product provides a 2'-O-methoxyethyl guanosine phosphoramidite identity.
How does it relate to 5'-O-DMT-2'-O-MOE-N2-isobutyrylguanosine?
It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.
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