Spacer-C3 Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
제품 개요
빠른 보기
- 제품군
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 분자식
- C33H43N2O5P
- 분자량
- 578.7
- 순도
- >=98.0% (HPLC)
Spacer-C3 Phosphoramidite is a non-nucleotide (abasic) spacer building block: a three-carbon (propyl) spacer carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 110894-23-0, molecular formula C33H43N2O5P, molecular weight 578.7, and PubChem CID 10303642.
Coupling inserts a non-nucleotide three-carbon spacer into the oligonucleotide backbone in place of a nucleotide — non-nucleotide chains can be incorporated into oligonucleotides this way (for example, to join segments or introduce a defined gap). The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.
동의어
DMT-O-C3-spacer 3'-CE phosphoramidite; 3-(DMTO)propyl non-nucleotide spacer amidite
식별 정보 및 규격
| Catalog No. | CH65096 |
| CAS No. | 110894-23-0 |
| Molecular Formula | C33H43N2O5P |
| Molecular Weight | 578.7 |
| PubChem CID | 10303642 |
| InChIKey | IMRNWKAKFIGPOS-UHFFFAOYSA-N |
| Purity | >=98.0% (HPLC) |
보관 조건
-20 C
기술 속성
- Reagent class
- Non-nucleotide spacer phosphoramidite
- Spacer type
- Alkyl
- Spacer length
- 3 carbons
- End protection
- 5'-O-DMT
- Grade
- N (Normal)
- Packaging
- 250 mg; 100 µmol; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- colorless viscous oily liquid
응용 맥락
- Non-nucleotide spacer insertion: introduces a three-carbon abasic spacer into the oligonucleotide backbone in place of a nucleotide.
- Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.
- Backbone linker: non-nucleotide chains can be incorporated into oligonucleotides to join segments or introduce a defined gap.
관련 기술 자료
공개 출처
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem 화합물 10303642
PubChem · CID 10303642
자주 묻는 질문
What is a spacer phosphoramidite?
It is a non-nucleotide (abasic) building block that inserts a spacer unit into the oligonucleotide backbone in place of a nucleotide. It couples through a 3'-phosphoramidite and carries a 5'-DMT (removed each cycle) so chain assembly continues normally.
What does the 'C3' mean?
C3 denotes the length of the spacer — a three-carbon (propyl) chain. Shorter (C2) and longer (C6, C12) variants and ethylene-glycol spacers give correspondingly different spacings.
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