Boc-NH-PEG2-CH2COOH
化学名称
2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid
Boc-NH-PEG2-CH2COOH•PROTAC
Structure: 
产品编号
CH56003
CAS
108466-89-3
分子式
C11H21NO6
分子量
263.29
规格标准
| Catalog No. | CH56003 |
| CAS No. | 108466-89-3 |
| Molecular Formula | C11H21NO6 |
| Molecular Weight | 263.29 |
品类工艺支持
CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.
概况
Boc-NH-PEG2-CH2COOH (also known as 2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]acetic acid) (CAS 108466-89-3, MF C11H21NO6, MW 263.29) is used as a PROTAC research building block in degrader chemistry. Typical chemistry questions involve route design for the bifunctional architecture, linker selection, and analytical control of residual reagents. Project scale-up and custom synthesis are coordinated by the CHEMOS R&D team across laboratory and production sites.
应用
- Boc-NH-PEG2-CH2COOH (108466-89-3) supply and analog preparation for research programs
- Reference material in targeted protein degradation chemistry programs
- PROTAC building block — linker / E3-ligand / degrader handle
- Bifunctional degrader synthesis with orthogonal protecting groups