Pomalidomide
化学名称
4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Pomalidomide•PROTAC
Structure: 
产品编号
CH56014
CAS
19171-19-8
分子式
C13H11N3O4
分子量
273.24
规格标准
| Catalog No. | CH56014 |
| CAS No. | 19171-19-8 |
| Molecular Formula | C13H11N3O4 |
| Molecular Weight | 273.24 |
品类工艺支持
CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.
概况
Pomalidomide (also known as 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione) (CAS 19171-19-8, MF C13H11N3O4, MW 273.24) is used as a PROTAC research building block in degrader chemistry. Typical chemistry questions involve route design for the bifunctional architecture, linker selection, and analytical control of residual reagents. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.
应用
- Pomalidomide (19171-19-8) as a starting point for downstream chemistry programs
- Reference material in targeted protein degradation chemistry programs
- Bifunctional degrader synthesis with orthogonal protecting groups
- Custom analog synthesis with controlled coupling handles