Triethylene glycol bis(p-toluenesulfonate)
化学名称
2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
Triethylene glycol bis(p-toluenesulfonate)•PROTAC
Structure: 
产品编号
CH56018
CAS
19249-03-7
分子式
C20H26O8S2
分子量
458.55
规格标准
| Catalog No. | CH56018 |
| CAS No. | 19249-03-7 |
| Molecular Formula | C20H26O8S2 |
| Molecular Weight | 458.55 |
品类工艺支持
CHEMOS supports PROTAC building-block projects covering linkers, E3 ligase recruiter derivatives, and customized degrader intermediates. Linker building blocks : PEG acids, PEG azides, alkyl spacers, branched linkers, and rigid linkers. E3 recruiter derivatives : IMiD-related, VHL-related, and other recruiter building blocks for medicinal chemistry programs. Custom synthesis : linker design, functional-group installation, and intermediate preparation. Route and purification review : multi-step synthesis planning with attention to polarity, solubility, and impurity control. Scale-up evaluation : larger-batch preparation can be assessed after route feasibility review.
概况
Triethylene glycol bis(p-toluenesulfonate) (also known as 2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethyl 4-methylbenzenesulfonate) (CAS 19249-03-7, MF C20H26O8S2, MW 458.55) is used as a PROTAC research building block in degrader chemistry. Typical chemistry questions involve route design for the bifunctional architecture, linker selection, and analytical control of residual reagents. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.
应用
- Triethylene glycol bis(p-toluenesulfonate) (19249-03-7) as a starting point for downstream chemistry programs
- Linker-length and composition exploration for degrader optimisation
- Process-development support for scalable building-block preparation
- PROTAC building block — linker / E3-ligand / degrader handle