HQ461
化学名称
2-[2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide
HQ461•Molecular Glues
Structure: 
产品编号
CH57011
CAS
1226443-41-9
分子式
C15H15N5OS2
分子量
345.44
规格标准
| Catalog No. | CH57011 |
| CAS No. | 1226443-41-9 |
| Molecular Formula | C15H15N5OS2 |
| Molecular Weight | 345.44 |
品类工艺支持
CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.
概况
HQ461 (also known as 2-[2-[(6-methyl-2-pyridinyl)amino]-1,3-thiazol-4-yl]-N-(5-methyl-1,3-thiazol-2-yl)acetamide) (CAS 1226443-41-9, MF C15H15N5OS2, MW 345.44) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. Bench-scale to larger-scale production is supported through CHEMOS organic chemistry workflows and dedicated process-development resources.
应用
- HQ461 (CAS 1226443-41-9) preparation, route refinement, and analytical-control planning
- Molecular glue research scaffold for targeted protein degradation
- Custom synthesis of analog series for SAR exploration
- Reference research scaffold in degrader chemistry programs