IKZF2-degrader 2
化学名称
3-[6-[5-chloro-1-methyl-4-(pyrrolidin-1-ylmethyl)pyrrolo[2,3-b]pyridin-6-yl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
IKZF2-degrader 2•Molecular Glues
Structure: 
产品编号
CH57017
CAS
2983841-00-3
分子式
C26H25ClFN5O3
分子量
509.96
规格标准
| Catalog No. | CH57017 |
| CAS No. | 2983841-00-3 |
| Molecular Formula | C26H25ClFN5O3 |
| Molecular Weight | 509.96 |
品类工艺支持
CHEMOS supports molecular glue and small-molecule degrader building-block chemistry, including analog preparation and route optimization. Scaffold preparation : IMiD-related analogs, sulfonamide motifs, and other functionalized small-molecule scaffolds. Custom analog synthesis : substituent variation, linker-ready handles, and SAR-oriented intermediate preparation. Chiral and stereochemical review : chiral separation or asymmetric synthesis can be evaluated where relevant. Analytical support : HPLC, NMR, MS, and purity-method development according to project needs. Process development : route refinement and scale-up planning after technical review.
概况
IKZF2-degrader 2 (also known as 3-[6-[5-chloro-1-methyl-4-(pyrrolidin-1-ylmethyl)pyrrolo[2,3-b]pyridin-6-yl]-7-fluoro-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione) (CAS 2983841-00-3, MF C26H25ClFN5O3, MW 509.96) is a small-molecule scaffold studied in targeted protein degradation research, with potential relevance to molecular glue or E3-ligase modulation chemistry. Practical chemistry topics include enantioselective synthesis, scaffold modification, and related-substance profiling. CHEMOS process chemistry, organic synthesis routes and project scale-up support are offered for downstream programs.
应用
- IKZF2-degrader 2 (CAS 2983841-00-3) preparation, route refinement, and analytical-control planning
- Custom synthesis of analog series for SAR exploration
- Process-development support for scalable scaffold preparation
- Reference research scaffold in degrader chemistry programs