CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

5-Methyluridine (Ribothymidine)

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

製品番号CH64014CAS番号1463-10-1純度>98.0% (HPLC, titration)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
化学名
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
分子式
C10H14N2O6
分子量
258.23
純度
>98.0% (HPLC, titration)

5-Methyluridine, also known as ribothymidine (rT), is a modified pyrimidine RNA nucleoside with 5-methyluracil linked to β-D-ribose. CH64014 is identified by CAS 1463-10-1, molecular formula C10H14N2O6, molecular weight 258.23, and PubChem CID 445408. It is distinct from thymidine (CH64004), which contains 2-deoxyribose.

In tRNA literature, ribothymidine is the conserved modified nucleoside at position 54 of the TΨC loop. This supports its use as a reference residue in tRNA-modification and modified-RNA chemistry research.

別名

5-Methyluridine; ribothymidine; rT; 5-methyluracil riboside; m5U

同定情報と仕様

Catalog No.CH64014
CAS No.1463-10-1
Molecular FormulaC10H14N2O6
Molecular Weight258.23
PubChem CID445408
InChIKeyDWRXFEITVBNRMK-JXOAFFINSA-N
Purity>98.0% (HPLC, titration)

保管条件

Room temperature; cool and dark place below 15 C; inert gas

技術属性

Nucleobase
5-Methyluracil
Sugar
D-Ribose
Base modification
5-Methyl
Nucleoside class
Modified pyrimidine ribonucleoside
Packaging
1 g glass bottle with plastic insert; Custom packaging on request
Water content
<=5.0%
Physical form
Solid; white to almost white powder to crystal

用途情報

  • tRNA-modification reference: 5-methyluridine is ribothymidine (rT), the conserved modified nucleoside at position 54 of the tRNA TΨC loop.
  • Modified RNA nucleoside reference: CH64014 provides the 5-methyluridine / ribothymidine identity for modified-RNA and nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

What is the difference between 5-methyluridine and thymidine?

5-Methyluridine (ribothymidine) is the RNA nucleoside — 5-methyluracil on ribose. Thymidine is the DNA nucleoside — the same base on 2-deoxyribose. They are cataloged separately.

Why is 5-methyluridine relevant to tRNA research?

As ribothymidine (rT), it is the conserved modified nucleoside at position 54 of the tRNA TΨC loop, so it is a reference residue in studies of tRNA modification.

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