CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2',3'-Dideoxyadenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64015CAS番号4097-22-7純度>98.0% (HPLC, titration)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C10H13N5O2
分子量
235.24
純度
>98.0% (HPLC, titration)

2',3'-Dideoxyadenosine (ddA) is a purine 2',3'-dideoxynucleoside with adenine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64015 is identified by CAS 4097-22-7, molecular formula C10H13N5O2, molecular weight 235.24, and PubChem CID 20039.

After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property is the basis for its chain-termination context in DNA-polymerase and dideoxy-sequencing research.

別名

2',3'-Dideoxyadenosine; ddA; 2',3'-dideoxyriboadenosine

同定情報と仕様

Catalog No.CH64015
CAS No.4097-22-7
Molecular FormulaC10H13N5O2
Molecular Weight235.24
PubChem CID20039
InChIKeyWVXRAFOPTSTNLL-NKWVEPMBSA-N
Purity>98.0% (HPLC, titration)

保管条件

Room temperature; cool and dark place below 15 C

技術属性

Nucleobase
Adenine
Sugar
2',3'-Dideoxyribose
Nucleoside class
Purine dideoxynucleoside
Research role
Chain-terminator nucleotide precursor
Packaging
100 mg; Custom packaging on request
Physical form
Solid; white to almost white powder to crystal

用途情報

  • Chain-terminator precursor: the corresponding ddATP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
  • DNA-polymerase research: ddA provides the adenine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
  • Dideoxynucleoside reference: CH64015 provides the 2',3'-dideoxyadenosine identity for nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why is 2',3'-dideoxyadenosine a chain terminator?

It lacks a 3'-hydroxyl, so once the corresponding ddNTP is incorporated by DNA polymerase, no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.

How is ddA different from 2'-deoxyadenosine?

2'-Deoxyadenosine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyadenosine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyadenosine is cataloged separately.

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