CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2',3'-Dideoxycytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64016CAS番号7481-89-2純度>=98.0% (HPLC)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C9H13N3O3
分子量
211.22
純度
>=98.0% (HPLC)

2',3'-Dideoxycytidine (ddC) is a pyrimidine 2',3'-dideoxynucleoside with cytosine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64016 is identified by CAS 7481-89-2, molecular formula C9H13N3O3, molecular weight 211.22, and PubChem CID 24066.

After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.

別名

2',3'-Dideoxycytidine; ddC; zalcitabine (research reagent naming)

同定情報と仕様

Catalog No.CH64016
CAS No.7481-89-2
Molecular FormulaC9H13N3O3
Molecular Weight211.22
PubChem CID24066
InChIKeyWREGKURFCTUGRC-POYBYMJQSA-N
Purity>=98.0% (HPLC)

保管条件

-20 C

技術属性

Nucleobase
Cytosine
Sugar
2',3'-Dideoxyribose
Nucleoside class
Pyrimidine dideoxynucleoside
Research role
Chain-terminator nucleotide precursor
Packaging
250 mg glass bottle with plastic insert; Custom packaging on request
Physical form
White to pale cream crystals or crystalline powder or powder

用途情報

  • Chain-terminator precursor: the corresponding ddCTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
  • DNA-polymerase research: ddC provides the cytidine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
  • Dideoxynucleoside reference: CH64016 provides the 2',3'-dideoxycytidine identity for nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why is 2',3'-dideoxycytidine a chain terminator?

It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.

How is ddC different from 2'-deoxycytidine?

2'-Deoxycytidine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxycytidine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxycytidine is cataloged separately.

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