CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2',3'-Dideoxyguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64017CAS番号85326-06-3純度>95.0% (HPLC, titration)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C10H13N5O3
分子量
251.24
純度
>95.0% (HPLC, titration)

2',3'-Dideoxyguanosine (ddG) is a purine 2',3'-dideoxynucleoside with guanine attached to a sugar lacking both the 2'- and 3'-hydroxyl groups. CH64017 is identified by CAS 85326-06-3, molecular formula C10H13N5O3, molecular weight 251.24, and PubChem CID 135463029.

After conversion to the corresponding triphosphate, the missing 3'-hydroxyl prevents further DNA-chain extension after polymerase incorporation. That property defines its chain-termination context in DNA-polymerase and dideoxy-sequencing research.

別名

2',3'-Dideoxyguanosine; ddG

同定情報と仕様

Catalog No.CH64017
CAS No.85326-06-3
Molecular FormulaC10H13N5O3
Molecular Weight251.24
PubChem CID135463029
InChIKeyOCLZPNCLRLDXJC-NTSWFWBYSA-N
Purity>95.0% (HPLC, titration)

保管条件

0-10 C

技術属性

Nucleobase
Guanine
Sugar
2',3'-Dideoxyribose
Nucleoside class
Purine dideoxynucleoside
Research role
Chain-terminator nucleotide precursor
Packaging
250 mg glass bottle with plastic insert; Custom packaging on request
Water content
<=2.0%
Physical form
Solid; white to light yellow powder to crystal

用途情報

  • Chain-terminator precursor: the corresponding ddGTP is incorporated by DNA polymerase as a chain-terminating nucleotide in dideoxy-sequencing research.
  • DNA-polymerase research: ddG provides the guanosine dideoxynucleoside identity for polymerase incorporation and chain-termination studies.
  • Dideoxynucleoside reference: CH64017 provides the 2',3'-dideoxyguanosine identity for nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why is 2',3'-dideoxyguanosine a chain terminator?

It lacks a 3'-hydroxyl, so once its triphosphate is incorporated by DNA polymerase no further nucleotide can be added and the chain terminates — the principle behind dideoxy sequencing.

How is ddG different from 2'-deoxyguanosine?

2'-Deoxyguanosine lacks only the 2'-hydroxyl and can extend a chain; 2',3'-dideoxyguanosine lacks both 2'- and 3'-hydroxyls and acts as a chain terminator. 2'-deoxyguanosine is cataloged separately.

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