CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Methyladenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64020CAS番号2140-79-6純度>98.0% (HPLC, titration)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C11H15N5O4
分子量
281.27
純度
>98.0% (HPLC, titration)

2'-O-Methyladenosine (2'-OMe-A, Am) is adenosine with a 2'-O-methyl group on the ribose. CH64020 is identified by CAS 2140-79-6, molecular formula C11H15N5O4, molecular weight 281.27, and PubChem CID 102213.

The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while natural 2'-O-methylation is treated as an RNA-modification reference.

別名

2'-O-Methyladenosine; 2'-OMe-A; Am

同定情報と仕様

Catalog No.CH64020
CAS No.2140-79-6
Molecular FormulaC11H15N5O4
Molecular Weight281.27
PubChem CID102213
InChIKeyFPUGCISOLXNPPC-IOSLPCCCSA-N
Purity>98.0% (HPLC, titration)

保管条件

Frozen below 0 C

技術属性

Nucleobase
Adenine
Sugar
D-Ribose
Sugar modification
2'-O-Methyl
Nucleoside class
Modified purine ribonucleoside
Packaging
1 g glass bottle with plastic insert; Custom packaging on request
Physical form
Solid; white to almost white powder to crystal
Stability
>=4 years

用途情報

  • Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
  • RNA-modification reference: 2'-O-methylation occurs naturally in RNA, making CH64020 relevant to tRNA/rRNA modification research.
  • 2'-OMe ribonucleoside reference: CH64020 provides the 2'-O-methyladenosine identity for nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

What does the 2'-O-methyl group do?

A 2'-O-methyl group on the ribose is associated with higher nuclease resistance while retaining RNA-binding affinity, so it is commonly studied in antisense and siRNA oligonucleotide research.

Is 2'-O-methyladenosine a natural RNA modification?

Yes. 2'-O-methylation (for example Am / Gm34) occurs naturally in tRNA and rRNA, so 2'-O-methyladenosine is also a reference in RNA-modification research.

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