CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-Methyluridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64023CAS番号2140-76-3純度>98.0% (HPLC, titration)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C10H14N2O6
分子量
258.23
純度
>98.0% (HPLC, titration)

2'-O-Methyluridine (2'-OMe-U, Um) is uridine with a 2'-O-methyl group on the ribose. CH64023 is identified by CAS 2140-76-3, molecular formula C10H14N2O6, molecular weight 258.23, and PubChem CID 102212. It has the same molecular formula as 5-methyluridine but a different methyl position and structure.

The same 2'-O-methyl motif appears in natural RNA modifications and in synthetic oligonucleotide research. In the cited literature, 2'-O-methyl ribonucleosides are discussed for nuclease resistance and RNA affinity, while Um is treated as a natural RNA-modification reference.

別名

2'-O-Methyluridine; 2'-OMe-U; Um

同定情報と仕様

Catalog No.CH64023
CAS No.2140-76-3
Molecular FormulaC10H14N2O6
Molecular Weight258.23
PubChem CID102212
InChIKeySXUXMRMBWZCMEN-ZOQUXTDFSA-N
Purity>98.0% (HPLC, titration)

保管条件

0-10 C

技術属性

Nucleobase
Uracil
Sugar
D-Ribose
Sugar modification
2'-O-Methyl
Nucleoside class
Modified pyrimidine ribonucleoside
Packaging
1 g glass bottle with plastic insert; 5 g listed size; Custom packaging on request
Physical form
Solid; white to almost white powder to crystal
Stability
>=4 years

用途情報

  • Nuclease-resistant oligonucleotide research: 2'-O-methyl residues are used as references for nuclease-resistant antisense and siRNA oligonucleotide studies.
  • RNA-modification reference: Um is a naturally occurring 2'-O-methyl RNA modification, making CH64023 relevant to RNA-modification research.
  • 2'-OMe ribonucleoside reference: CH64023 provides the 2'-O-methyluridine identity for nucleoside chemistry comparisons.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How is 2'-O-methyluridine different from 5-methyluridine?

Both share the formula C10H14N2O6, but 2'-O-methyluridine (Um) carries the methyl on the 2'-oxygen of the ribose, while 5-methyluridine (ribothymidine) carries it on carbon 5 of the base. They are constitutional isomers and are listed separately.

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