Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-Fluoro-2'-deoxyuridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64028CAS番号784-71-4純度>=99.0% (HPLC)

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製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C9H11FN2O5
分子量: 246.19
純度: >=99.0% (HPLC)

2'-Fluoro-2'-deoxyuridine (2'-F-dU) is a uridine analog in which the 2'-hydroxyl of the sugar is replaced by fluorine. CH64028 is identified by CAS 784-71-4, molecular formula C9H11FN2O5, molecular weight 246.19, and PubChem CID 150851. The fluorine is on the sugar, which distinguishes CH64028 from base-fluorinated 5-fluoro uridine derivatives.

The cited oligonucleotide literature discusses 2'-fluoro modifications in siRNA and antisense research for nuclease resistance and binding affinity. CH64028 provides the uridine 2'-fluoro-2'-deoxy nucleoside identity for related oligonucleotide-modification studies.

別名

2'-Fluoro-2'-deoxyuridine; 2'-F-dU; 2'-F-U

同定情報と仕様

Catalog No.	CH64028
CAS No.	784-71-4
Molecular Formula	C9H11FN2O5
Molecular Weight	246.19
PubChem CID	150851
InChIKey	UIYWFOZZIZEEKJ-XVFCMESISA-N
Purity	>=99.0% (HPLC)

保管条件

4 C

技術属性

Nucleobase: Uracil
Sugar modification: 2'-Fluoro-2'-deoxy
Nucleoside class: 2'-Fluoro pyrimidine nucleoside
Packaging: Custom packaging on request
Water content: <=3.0% KF
Physical form: White crystalline powder
Stability: >=4 years

用途情報

2'-F oligonucleotide research: CH64028 is relevant to siRNA and antisense modification studies involving 2'-fluoro uridine residues.
Modified-nucleic-acid studies: the 2'-fluoro motif is discussed in duplex-affinity and nuclease-resistance research on modified oligonucleotides.
2'-F nucleoside reference: CH64028 provides the 2'-fluoro-2'-deoxyuridine identity for nucleoside chemistry research.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 150851
PubChem · CID 150851

よくある質問

Is this 2'-fluoro or 5-fluoro uridine?

It is 2'-fluoro-2'-deoxyuridine — the fluorine is on the 2' position of the sugar. It is different from 5-fluoro uridine derivatives, where the fluorine is on the uracil base.