Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-(2-Methoxyethyl)adenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64029CAS番号168427-74-5純度>=98%

製品画像はありません

製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C13H19N5O5
分子量: 325.32
純度: >=98%

2'-O-(2-Methoxyethyl)adenosine (2'-O-MOE-A) is adenosine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64029 is identified by CAS 168427-74-5, molecular formula C13H19N5O5, molecular weight 325.32, and PubChem CID 11393191.

In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64029 provides the adenosine 2'-O-MOE nucleoside identity for related antisense-oligonucleotide research.

別名

2'-O-(2-Methoxyethyl)adenosine; 2'-O-MOE-A; 2'-MOE-A

同定情報と仕様

Catalog No.	CH64029
CAS No.	168427-74-5
Molecular Formula	C13H19N5O5
Molecular Weight	325.32
PubChem CID	11393191
InChIKey	PUDXUJRJLRLJIU-QYVSTXNMSA-N
Purity	>=98%

保管条件

-20 C

技術属性

Nucleobase: Adenine
Sugar: D-Ribose
Sugar modification: 2'-O-(2-Methoxyethyl) (MOE)
Nucleoside class: MOE-modified purine ribonucleoside
Packaging: 250 mg; 500 mg; 1 g; 2 g; Custom packaging on request
Physical form: Solid
Stability: >=4 years

用途情報

MOE gapmer antisense research: CH64029 is relevant to gapmer antisense studies involving 2'-O-MOE adenine residues.
Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
2'-O-MOE nucleoside reference: CH64029 provides the 2'-O-(2-methoxyethyl)adenosine identity for nucleoside chemistry research.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 11393191
PubChem · CID 11393191

よくある質問

How is 2'-O-MOE-adenosine different from 2'-O-methyladenosine?

Both are 2'-O-alkyl modifications, but MOE is a larger 2-methoxyethyl group versus a single methyl in 2'-O-methyl. 2'-O-methyladenosine is cataloged separately.