2'-O-(2-Methoxyethyl)-5-methylcytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidin-2-one
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 化学名
- 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]-5-methylpyrimidin-2-one
- 分子式
- C13H21N3O6
- 分子量
- 315.32
- 純度
- >=98% (HPLC)
2'-O-(2-Methoxyethyl)-5-methylcytidine (2'-O-MOE-5-Me-C) is 5-methylcytidine with a 2'-O-(2-methoxyethyl) group on the ribose. CH64030 is identified by CAS 244105-55-3, molecular formula C13H21N3O6, molecular weight 315.32, and PubChem CID 18345944.
In the cited structure and stability literature, 2'-O-MOE ribonucleosides are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. CH64030 provides the corrected 2'-O-MOE-5-methylcytidine identity for related antisense-oligonucleotide research.
別名
2'-O-(2-Methoxyethyl)-5-methylcytidine; 2'-O-MOE-5-Me-C; MOE-5-methyl-C
同定情報と仕様
| Catalog No. | CH64030 |
| CAS No. | 244105-55-3 |
| Molecular Formula | C13H21N3O6 |
| Molecular Weight | 315.32 |
| PubChem CID | 18345944 |
| InChIKey | GUEIFVRYWPOXHJ-DNRKLUKYSA-N |
| Purity | >=98% (HPLC) |
保管条件
2-8 C
技術属性
- Nucleobase
- 5-Methylcytosine
- Sugar
- D-Ribose
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Nucleoside class
- MOE-modified pyrimidine ribonucleoside
- Packaging
- 500 mg; 1 g; 2 g; 5 g; Custom packaging on request
- Water content
- <=7% KF
- Physical form
- Powder; white to off-white
用途情報
- MOE gapmer antisense research: CH64030 is relevant to gapmer antisense studies involving 2'-O-MOE 5-methyl-C residues.
- Modified-nucleic-acid studies: cited literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies of modified oligonucleotides.
- MOE nucleoside reference: CH64030 provides the 2'-O-(2-methoxyethyl)-5-methylcytidine identity for nucleoside chemistry research.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 18345944
PubChem · CID 18345944
よくある質問
Is CH64030 a uridine or a cytidine?
CH64030 is a cytidine derivative: it has a 5-methylcytosine base and a 2'-O-(2-methoxyethyl) ribose modification.
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