N6-Acetyl-2'-deoxyadenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C12H15N5O4
- 分子量
- 293.28
- 純度
- >=97% (HPLC)
N6-Acetyl-2'-deoxyadenosine (dAAc) is 2'-deoxyadenosine whose adenine exocyclic N6-amine is protected with an acetyl group. CH64076 is identified by CAS 1443367-96-1, molecular formula C12H15N5O4, molecular weight 293.28, PubChem CID 23275717, and InChIKey DKVIBEFOBOVION-UHFFFAOYSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups on nucleobases and their removal during deprotection. CH64076 provides the N6-acetyl-protected 2'-deoxyadenosine identity for DNA building-block and nucleoside chemistry research.
別名
N6-Acetyl-2'-deoxyadenosine; N6-Ac-dA; dAAc
同定情報と仕様
| Catalog No. | CH64076 |
| CAS No. | 1443367-96-1 |
| Molecular Formula | C12H15N5O4 |
| Molecular Weight | 293.28 |
| PubChem CID | 23275717 |
| InChIKey | DKVIBEFOBOVION-UHFFFAOYSA-N |
| Purity | >=97% (HPLC) |
保管条件
Solid product: 2-8 C; user-prepared stock solution: -80 C or -20 C
技術属性
- Nucleobase
- Adenine
- Sugar
- 2'-Deoxyribose
- Base protection
- N6-Acetyl
- Synthesis role
- Base-protected DNA nucleoside intermediate
- Packaging
- 25 mg; 100 mg; 250 mg; 1 g; 10 g; Custom packaging on request
- Solution concentration
- 10 mM in 25 uL sample solution only
- Stability
- User-prepared stock solution: 6 months at -80 C; 1 month at -20 C
用途情報
- Base-protected DNA building block: the N6-acetyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- Adenine (dA) monomer precursor context: CH64076 is the acetyl-protected 2'-deoxyadenosine identity relevant to adenine building-block preparation.
- Nucleoside chemistry reference: CH64076 provides the N6-acetyl-2'-deoxyadenosine (dAAc) identity for nucleoside chemistry research.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 23275717
PubChem · CID 23275717
よくある質問
Why is the N6-amine of this deoxyadenosine acetylated?
In oligonucleotide synthesis the reactive exocyclic amine of adenine is masked with a protecting group such as acetyl to prevent side reactions; the acetyl group is later removed during deprotection.
How does it differ from N6-benzoyl-2'-deoxyadenosine?
Both protect the adenine N6-amine, but this one uses an acetyl group rather than benzoyl. N6-benzoyl-2'-deoxyadenosine is cataloged separately.
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