Oligonucleotide Synthesis, RNA Raw Materials & Modification

N2-(Dimethylaminomethylene)-2'-O-methylguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64089CAS番号183737-04-4純度>=97.0% (HPLC)

製品画像はありません

製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C14H20N6O5
分子量: 352.35
純度: >=97.0% (HPLC)

N2-(Dimethylaminomethylene)-2'-O-methylguanosine is 2'-O-methylguanosine whose guanine exocyclic N2-amine is protected with a dimethylformamidine (dmf) group. CH64089 is identified by CAS 183737-04-4, molecular formula C14H20N6O5, molecular weight 352.35, PubChem CID 136119103, and InChIKey KDQQTCFKBCWYFL-QYVSTXNMSA-N.

The cited oligonucleotide-synthesis literature discusses dimethylformamidine as a labile guanine base-protecting group and its removal during deprotection. In the cited 2'-O-methyl literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

別名

N2-(Dimethylaminomethylene)-2'-O-methylguanosine; N2-dmf-2'-OMe-rG; 2'-OMe-rG(dmf)

同定情報と仕様

Catalog No.	CH64089
CAS No.	183737-04-4
Molecular Formula	C14H20N6O5
Molecular Weight	352.35
PubChem CID	136119103
InChIKey	KDQQTCFKBCWYFL-QYVSTXNMSA-N
Purity	>=97.0% (HPLC)

保管条件

2-8 C

技術属性

Nucleobase: Guanine
Sugar modification: 2'-O-Methyl
Base protection: N2-Dimethylaminomethylene (dmf)
Synthesis role: Base-protected 2'-O-methyl nucleoside intermediate
Packaging: 10 mg; 50 mg; Custom packaging on request
Water content: <=2.0%
Physical form: white off-white to faint yellow powder
Stability: Powder: 3 years at -20 C; in solvent: 1 year at -80 C

用途情報

Base-protected 2'-OMe building block: the N2-dmf group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-OMe sugar modification context: cited 2'-O-methyl literature discusses 2'-OMe residues for nuclease resistance and RNA affinity.
Nucleoside chemistry reference: CH64089 provides the N2-dmf-2'-O-methylguanosine identity for nucleoside chemistry research.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 136119103
PubChem · CID 136119103

よくある質問

How does it differ from N2-dmf-2'-deoxyguanosine?

Both carry an N2-dmf-protected guanine, but this one is a ribonucleoside with a 2'-O-methyl sugar modification, while N2-dmf-2'-deoxyguanosine is the 2'-deoxy form. That one is cataloged separately.