2'-O-MOE-N6-Benzoyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C20H23N5O6
- 分子量
- 429.43
- 純度
- >=97%
2'-O-MOE-N6-Benzoyladenosine is 2'-O-(2-methoxyethyl)adenosine whose adenine exocyclic N6-amine is protected with a benzoyl group. CH64095 is identified by CAS 333335-93-6, molecular formula C20H23N5O6, molecular weight 429.43, PubChem CID 21348490, and InChIKey RUFJMCSVNNGZFB-KHTYJDQRSA-N.
The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
別名
2'-O-MOE-N6-Benzoyladenosine; 2'-O-(2-methoxyethyl)-N6-benzoyladenosine; MOE-rA(Bz)
同定情報と仕様
| Catalog No. | CH64095 |
| CAS No. | 333335-93-6 |
| Molecular Formula | C20H23N5O6 |
| Molecular Weight | 429.43 |
| PubChem CID | 21348490 |
| InChIKey | RUFJMCSVNNGZFB-KHTYJDQRSA-N |
| Purity | >=97% |
保管条件
2-8 C
技術属性
- Nucleobase
- Adenine
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N6-Benzoyl
- Synthesis role
- Base-protected MOE nucleoside intermediate
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; Custom packaging on request
- Water content
- <=2.0%
- Physical form
- white to off-white powder
- Stability
- Powder: 3 years at -20 C; in solvent: 1 year at -80 C
用途情報
- Base-protected 2'-O-MOE building block: the N6-benzoyl group masks the adenine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
- 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
- Nucleoside chemistry identity: a defined 2'-O-MOE-N6-benzoyladenosine compound for nucleoside chemistry research.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 21348490
PubChem · CID 21348490
よくある質問
How does it differ from N6-benzoyl-2'-O-methyladenosine?
Both are N6-benzoyl base-protected adenosines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.
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