Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-MOE-N4-Benzoylcytidine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64096CAS番号2305416-18-4純度>=98%

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製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C19H23N3O7
分子量: 405.40
純度: >=98%

2'-O-MOE-N4-Benzoylcytidine is 2'-O-(2-methoxyethyl)cytidine whose cytosine exocyclic N4-amine is protected with a benzoyl group. CH64096 is identified by CAS 2305416-18-4, molecular formula C19H23N3O7, molecular weight 405.40, PubChem CID 168449060, and InChIKey VDTLYOJAWYZWEE-GFOCRRMGSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.

別名

2'-O-MOE-N4-Benzoylcytidine; 2'-O-(2-methoxyethyl)-N4-benzoylcytidine; MOE-rC(Bz)

同定情報と仕様

Catalog No.	CH64096
CAS No.	2305416-18-4
Molecular Formula	C19H23N3O7
Molecular Weight	405.40
PubChem CID	168449060
InChIKey	VDTLYOJAWYZWEE-GFOCRRMGSA-N
Purity	>=98%

保管条件

2-8 C

技術属性

Nucleobase: Cytosine
Sugar modification: 2'-O-(2-Methoxyethyl) (MOE)
Base protection: N4-Benzoyl
Synthesis role: Base-protected MOE nucleoside intermediate
Packaging: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
Physical form: white to off-white powder
Stability: Powder: 3 years at -20 C; in solvent: 1 year at -80 C

用途情報

Base-protected 2'-O-MOE building block: the N4-benzoyl group masks the cytosine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
Nucleoside chemistry identity: a defined 2'-O-MOE-N4-benzoylcytidine compound for nucleoside chemistry research.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 168449060
PubChem · CID 168449060

よくある質問

How does it differ from N4-benzoyl-2'-O-methylcytidine?

Both are N4-benzoyl base-protected cytidines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.