CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-MOE-N2-Isobutyrylguanosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64098CAS番号440327-50-4純度>=98%
製品画像はありません

製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C17H25N5O7
分子量
411.41
純度
>=98%

2'-O-MOE-N2-Isobutyrylguanosine is 2'-O-(2-methoxyethyl)guanosine whose guanine exocyclic N2-amine is protected with an isobutyryl group. CH64098 is identified by CAS 440327-50-4, molecular formula C17H25N5O7, molecular weight 411.41, PubChem CID 136162613, and InChIKey IZOOGJIUOCHAAY-UBEDBUPSSA-N.

The cited oligonucleotide-synthesis literature discusses exocyclic-amine protecting groups and their removal during deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.

別名

2'-O-MOE-N2-Isobutyrylguanosine; 2'-O-(2-methoxyethyl)-N2-isobutyrylguanosine; MOE-rG(iBu)

同定情報と仕様

Catalog No.CH64098
CAS No.440327-50-4
Molecular FormulaC17H25N5O7
Molecular Weight411.41
PubChem CID136162613
InChIKeyIZOOGJIUOCHAAY-UBEDBUPSSA-N
Purity>=98%

保管条件

2-8 C

技術属性

Nucleobase
Guanine
Sugar modification
2'-O-(2-Methoxyethyl) (MOE)
Base protection
N2-Isobutyryl
Synthesis role
Base-protected MOE nucleoside intermediate
Packaging
5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 10 g; 100 g; 1 kg; Custom packaging on request
Water content
<=2.0%
Physical form
white to off-white powder
Stability
Powder: 3 years at -20 C; in solvent: 1 year at -80 C

用途情報

  • Base-protected 2'-O-MOE building block: the N2-isobutyryl group masks the guanine exocyclic amine in oligonucleotide-synthesis chemistry and is removed during deprotection.
  • 2'-O-MOE modification context: cited structure and stability literature discusses 2'-O-MOE residues in relation to RNA affinity, nuclease resistance, and gapmer flanking residues.
  • Nucleoside chemistry identity: a defined 2'-O-MOE-N2-isobutyrylguanosine compound for nucleoside chemistry research.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from N2-isobutyryl-2'-O-methylguanosine?

Both are N2-isobutyryl base-protected guanosines, but this one has a 2'-O-methoxyethyl (2'-MOE) sugar modification rather than 2'-O-methyl. The 2'-OMe form is cataloged separately.

類似製品

2',3',5'-Tri-O-acetyl-D-adenosine

CAS番号
7387-57-7
分子式
C16H19N5O7
分子量
393.35

L-Threoninol

CAS番号
3228-51-1
分子式
C4H11NO2
分子量
105.14

Tetrabenzyl pyrophosphate

CAS番号
990-91-0
分子式
C28H28O7P2
分子量
538.47

2'-Deoxyadenosine Monohydrate

CAS番号
16373-93-6
分子式
C10H15N5O4
分子量
269.26

材料選択の支援が必要ですか？

CHEMOSは製品適合性、目標構造、ルート上の課題、分析要件、プロジェクト別供給ニーズを確認します。

プロジェクト支援を見る