Oligonucleotide Synthesis, RNA Raw Materials & Modification

5'-O-DMT-N6-benzoyl-2'-O-methyladenosine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64116CAS番号110764-72-2純度>=99%

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製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C39H37N5O7
分子量: 687.7
純度: >=99%

5'-O-DMT-N6-benzoyl-2'-O-methyladenosine is 2'-O-methyladenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64116 is identified by CAS 110764-72-2, molecular formula C39H37N5O7, molecular weight 687.7, PubChem CID 10770884, and InChIKey SARHDAQOZNKZCC-CJEGOSRCSA-N.

It is a 2'-OMe-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

別名

5'-O-DMT-N6-benzoyl-2'-O-methyladenosine; 5'-O-DMT-2'-OMe-rA(Bz); DMT-2'-OMe-rA(Bz)

同定情報と仕様

Catalog No.	CH64116
CAS No.	110764-72-2
Molecular Formula	C39H37N5O7
Molecular Weight	687.7
PubChem CID	10770884
InChIKey	SARHDAQOZNKZCC-CJEGOSRCSA-N
Purity	>=99%

保管条件

2-8 C

技術属性

Nucleobase: Adenine
5'-O protection: DMT (dimethoxytrityl)
Sugar modification: 2'-O-Methyl
Base protection: N6-Benzoyl
Grade: N (Normal)
Packaging: 100 mg; 250 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; Custom packaging on request
Water content: <=1.0%
Physical form: white to off-white powder

用途情報

5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
2'-OMe modification context: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 10770884
PubChem · CID 10770884

よくある質問

How does it differ from N6-benzoyl-2'-O-methyladenosine?

Both carry an N6-benzoyl-protected 2'-O-methyladenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.