CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

5'-O-DMT-5-methyl-2'-O-methyluridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64119CAS番号153631-19-7純度>=98%
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C32H34N2O8
分子量
574.6
純度
>=98%

5'-O-DMT-5-methyl-2'-O-methyluridine is 2'-O-methyl-5-methyluridine (its base is 5-methyluracil) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64119 is identified by CAS 153631-19-7, molecular formula C32H34N2O8, molecular weight 574.6, PubChem CID 10438068, and InChIKey VFLOXJCZWDDILQ-NODMTMHWSA-N.

It is a 2'-OMe-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity. Because the 5-methyluracil base has no exocyclic amine, no base protecting group is required.

別名

5'-O-DMT-5-methyl-2'-O-methyluridine; 5'-O-DMT-2'-OMe-5-methyl-rU; DMT-2'-OMe-5Me-rU

同定情報と仕様

Catalog No.CH64119
CAS No.153631-19-7
Molecular FormulaC32H34N2O8
Molecular Weight574.6
PubChem CID10438068
InChIKeyVFLOXJCZWDDILQ-NODMTMHWSA-N
Purity>=98%

保管条件

2-8 C

技術属性

Nucleobase
5-Methyluracil
5'-O protection
DMT (dimethoxytrityl)
Sugar modification
2'-O-Methyl
Base protection
Unprotected
Packaging
100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; Custom packaging on request
Water content
<=1.0%
Physical form
white to off-white powder

用途情報

  • 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
  • 2'-OMe modification context: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
  • No base protection needed: the 5-methyluracil base has no exocyclic amine, so this building block requires no base protecting group.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from 5'-O-DMT-2'-O-methyluridine?

This one has a 5-methyluracil base (an extra methyl on the base), whereas 5'-O-DMT-2'-O-methyluridine has a plain uracil base. That one is cataloged separately.

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