5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-deoxyguanosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C35H36FN5O7
- 分子量
- 657.7
- 純度
- >=99%
5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-deoxyguanosine is 2'-fluoro-2'-deoxyguanosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N2-isobutyryl base-protecting group. CH64123 is identified by CAS 144089-96-3, molecular formula C35H36FN5O7, molecular weight 657.7, PubChem CID 135453718, and InChIKey QQQXVSXVBFQISZ-UNVYQVKTSA-N.
It is a 2'-F-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N2-isobutyryl group masks the guanine exocyclic amine and is removed at final deprotection. The cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
別名
5'-O-DMT-2'-fluoro-N2-isobutyryl-2'-deoxyguanosine; 5'-O-DMT-2'-F-rG(iBu); DMT-2'-F-rG(iBu)
同定情報と仕様
| Catalog No. | CH64123 |
| CAS No. | 144089-96-3 |
| Molecular Formula | C35H36FN5O7 |
| Molecular Weight | 657.7 |
| PubChem CID | 135453718 |
| InChIKey | QQQXVSXVBFQISZ-UNVYQVKTSA-N |
| Purity | >=99% |
保管条件
2-8 C, tightly closed, protected from light and humidity
技術属性
- Nucleobase
- Guanine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-Fluoro-2'-deoxy
- Base protection
- N2-Isobutyryl
- Grade
- N (Normal)
- Packaging
- 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 50 g; 100 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white, off-white to faint yellow powder
- Stability
- Powder: 3 years at -20 C; 2 years at 4 C; in solvent: 6 months at -80 C; 1 month at -20 C
用途情報
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-Fluoro sugar modification: cited oligonucleotide literature discusses 2'-fluoro modifications in relation to RNA affinity and nuclease resistance.
- N2-isobutyryl base protection: the isobutyryl group masks the guanine exocyclic amine during synthesis and is removed at final deprotection.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 135453718
PubChem · CID 135453718
よくある質問
How does it differ from N2-isobutyryl-2'-fluoro-2'-deoxyguanosine?
Both carry an N2-isobutyryl-protected 2'-fluoro guanosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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