5'-O-DMT-2'-O-MOE-N6-benzoyladenosine
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C41H41N5O8
- 分子量
- 731.8
- 純度
- >=99%
5'-O-DMT-2'-O-MOE-N6-benzoyladenosine is 2'-O-(2-methoxyethyl)adenosine carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group and an N6-benzoyl base-protecting group. CH64126 is identified by CAS 251647-48-0, molecular formula C41H41N5O8, molecular weight 731.8, PubChem CID 21107951, and InChIKey KEVMXGNDTKPSMC-MUMPVVMASA-N.
It is a 2'-O-MOE-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle, and the N6-benzoyl group masks the adenine exocyclic amine and is removed at final deprotection. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.
別名
5'-O-DMT-2'-O-MOE-N6-benzoyladenosine; 5'-O-DMT-2'-O-(2-methoxyethyl)-N6-Bz-rA; DMT-2'-MOE-rA(Bz)
同定情報と仕様
| Catalog No. | CH64126 |
| CAS No. | 251647-48-0 |
| Molecular Formula | C41H41N5O8 |
| Molecular Weight | 731.8 |
| PubChem CID | 21107951 |
| InChIKey | KEVMXGNDTKPSMC-MUMPVVMASA-N |
| Purity | >=99% |
保管条件
2-8 C, tightly closed, protected from light and humidity
技術属性
- Nucleobase
- Adenine
- 5'-O protection
- DMT (dimethoxytrityl)
- Sugar modification
- 2'-O-(2-Methoxyethyl) (MOE)
- Base protection
- N6-Benzoyl
- Grade
- N (Normal)
- Packaging
- 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; Custom packaging on request
- Water content
- <=1.0%
- Physical form
- white, off-white to faint yellow powder
用途情報
- 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
- 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies.
- N6-benzoyl base protection: the benzoyl group masks the adenine exocyclic amine during synthesis and is removed at final deprotection.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 21107951
PubChem · CID 21107951
よくある質問
How does it differ from 2'-O-MOE-N6-benzoyladenosine?
Both carry an N6-benzoyl-protected 2'-O-MOE adenosine, but this one also has a 5'-O-DMT group on the 5'-hydroxyl (as a phosphoramidite precursor). The non-DMT form is cataloged separately.
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