CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

5'-O-DMT-2'-O-MOE-5-methyluridine

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH64129CAS番号163759-50-0純度99%
製品画像はありません

製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C34H38N2O9
分子量
618.7
純度
99%

5'-O-DMT-2'-O-MOE-5-methyluridine is 2'-O-(2-methoxyethyl)-5-methyluridine (its base is 5-methyluracil) carrying a 5'-O-(4,4'-dimethoxytrityl) (DMT) group. CH64129 is identified by CAS 163759-50-0, molecular formula C34H38N2O9, molecular weight 618.7, PubChem CID 15864049, and InChIKey WIPCVBQXKBWNRC-PBAMLIMUSA-N.

It is a 2'-O-MOE-modified RNA phosphoramidite precursor context: the acid-labile 5'-DMT group is removed at the start of each chain-elongation cycle. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides. Because the 5-methyluracil base has no exocyclic amine, no base protecting group is required.

別名

5'-O-DMT-2'-O-MOE-5-methyluridine; DMT-2'-MOE-5Me-rU

同定情報と仕様

Catalog No.CH64129
CAS No.163759-50-0
Molecular FormulaC34H38N2O9
Molecular Weight618.7
PubChem CID15864049
InChIKeyWIPCVBQXKBWNRC-PBAMLIMUSA-N
Purity99%

保管条件

2-8 C

技術属性

Nucleobase
5-Methyluracil
5'-O protection
DMT (dimethoxytrityl)
Sugar modification
2'-O-(2-Methoxyethyl) (MOE)
Base protection
Unprotected
Grade
N (Normal)
Packaging
5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 100 g; 1 kg; Custom packaging on request
Water content
<=1.0%
Physical form
white to off-white powder

用途情報

  • 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group protects the 5'-hydroxyl and is removed at the start of each RNA chain-elongation cycle.
  • 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies.
  • No base protection needed: the 5-methyluracil base has no exocyclic amine, so this building block requires no base protecting group.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from 5'-O-DMT-5-methyl-2'-O-methyluridine?

Both are 5'-O-DMT-protected 5-methyluridines, but this one has a 2'-O-methoxyethyl (2'-MOE) modification, whereas the other has a 2'-O-methyl modification. The 2'-OMe form is cataloged separately.

類似製品

2',3',5'-Tri-O-acetyl-D-adenosine

CAS番号
7387-57-7
分子式
C16H19N5O7
分子量
393.35

L-Threoninol

CAS番号
3228-51-1
分子式
C4H11NO2
分子量
105.14

Tetrabenzyl pyrophosphate

CAS番号
990-91-0
分子式
C28H28O7P2
分子量
538.47

2'-Deoxyadenosine Monohydrate

CAS番号
16373-93-6
分子式
C10H15N5O4
分子量
269.26

材料選択の支援が必要ですか？

CHEMOSは製品適合性、目標構造、ルート上の課題、分析要件、プロジェクト別供給ニーズを確認します。

プロジェクト支援を見る