CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-Deoxyinosine CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65008CAS番号141684-35-7純度99% (NMR)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C40H47N6O7P
分子量
754.8
純度
99% (NMR)

2'-Deoxyinosine CE Phosphoramidite is the 2'-deoxyinosine building block for DNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine (hypoxanthine base) bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65008 is identified by CAS 141684-35-7, molecular formula C40H47N6O7P, molecular weight 754.8, PubChem CID 135741319, and InChIKey ZKGZROFWRPJVEB-XZYUMQGLSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite is the reactive group that couples to the growing chain, and the acid-labile 5'-DMT is removed at the start of each cycle. Because the hypoxanthine base has no exocyclic amine, no base protecting group is required.

別名

DMT-dI phosphoramidite; 5'-O-DMT-2'-deoxyinosine 3'-CE phosphoramidite

同定情報と仕様

Catalog No.CH65008
CAS No.141684-35-7
Molecular FormulaC40H47N6O7P
Molecular Weight754.8
PubChem CID135741319
InChIKeyZKGZROFWRPJVEB-XZYUMQGLSA-N
Purity99% (NMR)

保管条件

at or below -20 C

技術属性

Monomer class
DNA CE phosphoramidite
Nucleobase
Hypoxanthine
5'-O protection
DMT (dimethoxytrityl)
Base protection
Unprotected
Grade
Standard
Packaging
250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g; 200 g; 100 µmol; Custom packaging on request
Water content
K.F. <=0.20% w/w
Coupling efficiency
spec >=98.0% and observed 98.0%
Physical form
powder
Stability
Manufactured 2021-12-30; retest 2025-07-02; expired 2025-12-29

用途情報

  • DNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 5'-DMT 5'-OH protection: the acid-labile 4,4'-dimethoxytrityl group is removed at the start of each chain-elongation cycle.
  • No base protection needed: the hypoxanthine base has no exocyclic amine, so this monomer requires no base protecting group.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why does the 2'-deoxyinosine phosphoramidite have no base protecting group?

The hypoxanthine base of 2'-deoxyinosine has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile 5'-O-DMT group (removed each cycle) and the 3'-phosphoramidite coupling group.

How does it relate to 5'-O-DMT-2'-deoxyinosine?

It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The 5'-O-DMT-2'-deoxyinosine precursor is cataloged separately.

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