CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-OMe-Cytidine (Ac) CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65018CAS番号199593-09-4純度>=99% (NMR)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C42H52N5O9P
分子量
801.9
純度
>=99% (NMR)

2'-OMe-Cytidine (Ac) CE Phosphoramidite is the 2'-O-methyl cytidine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-2'-O-methylcytidine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65018 is identified by CAS 199593-09-4, molecular formula C42H52N5O9P, molecular weight 801.9, PubChem CID 66764086, and InChIKey WNWUMIPFLOKTEZ-UAQIPLLRSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

別名

DMT-2'-OMe-rC(Ac) phosphoramidite; 5'-O-DMT-N4-acetyl-2'-O-methylcytidine 3'-CE phosphoramidite

同定情報と仕様

Catalog No.CH65018
CAS No.199593-09-4
Molecular FormulaC42H52N5O9P
Molecular Weight801.9
PubChem CID66764086
InChIKeyWNWUMIPFLOKTEZ-UAQIPLLRSA-N
Purity>=99% (NMR)

保管条件

-20 C; under inert atmosphere

技術属性

Monomer class
2'-O-methyl RNA CE phosphoramidite
Nucleobase
Cytosine
Sugar modification
2'-O-Methyl
Base protection
N4-Acetyl
Grade
Standard; TheraPure
Packaging
250 mg; 500 mg; 1 g; 5 g; 10 g; 100 g; Custom packaging on request
Water content
<=0.3 wt.% by Karl Fischer
Physical form
white to off-white powder
Stability
>=4 years

用途情報

  • 2'-OMe RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 2'-OMe sugar modification: cited literature discusses 2'-O-methyl residues in relation to nuclease resistance and RNA affinity.
  • 5'-DMT + N4-acetyl protection: the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from the 2'-OMe-C(Bz) phosphoramidite?

Both are 2'-O-methyl cytidine amidites, but this one uses an N4-acetyl base protection rather than benzoyl. The benzoyl amidite is cataloged separately.

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