CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-OMe-Guanosine (iBu) CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65019CAS番号150780-67-9純度100% (NMR)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C45H56N7O9P
分子量
869.9
純度
100% (NMR)

2'-OMe-Guanosine (iBu) CE Phosphoramidite is the 2'-O-methyl guanosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-O-methylguanosine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65019 is identified by CAS 150780-67-9, molecular formula C45H56N7O9P, molecular weight 869.9, PubChem CID 135587728, and InChIKey IRRDHRZUOZNWDJ-MLLDKZSOSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

別名

DMT-2'-OMe-rG(iBu) phosphoramidite; 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine 3'-CE phosphoramidite

同定情報と仕様

Catalog No.CH65019
CAS No.150780-67-9
Molecular FormulaC45H56N7O9P
Molecular Weight869.9
PubChem CID135587728
InChIKeyIRRDHRZUOZNWDJ-MLLDKZSOSA-N
Purity100% (NMR)

保管条件

-20 C

技術属性

Monomer class
2'-O-methyl RNA CE phosphoramidite
Nucleobase
Guanine
Sugar modification
2'-O-Methyl
Base protection
N2-Isobutyryl
Grade
N (Normal)
Packaging
250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g; 200 g; 500 g; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder
Stability
Manufactured 2019-08-16; retest 2023-02-16; expired 2023-08-15

用途情報

  • 2'-OMe RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 2'-OMe sugar modification: cited 2'-O-methyl oligonucleotide literature discusses nuclease resistance and RNA affinity.
  • 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it relate to 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine?

It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.

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