CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-OMe-Inosine CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65022CAS番号128219-85-2純度>=98.0% (HPLC)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C41H49N6O8P
分子量
784.8
純度
>=98.0% (HPLC)

2'-OMe-Inosine CE Phosphoramidite is the 2'-O-methyl inosine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methylinosine (hypoxanthine base) bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65022 is identified by CAS 128219-85-2, molecular formula C41H49N6O8P, molecular weight 784.8, PubChem CID 135742511, and InChIKey PVFNTYBGWVZMCX-HLHZJIEZSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain and the acid-labile 5'-DMT is removed each cycle. Because the hypoxanthine base has no exocyclic amine, no base protecting group is required. In the cited literature, 2'-O-methyl ribonucleosides/residues are discussed for nuclease resistance and RNA affinity.

別名

DMT-2'-OMe-rI phosphoramidite; 5'-O-DMT-2'-O-methylinosine 3'-CE phosphoramidite

同定情報と仕様

Catalog No.CH65022
CAS No.128219-85-2
Molecular FormulaC41H49N6O8P
Molecular Weight784.8
PubChem CID135742511
InChIKeyPVFNTYBGWVZMCX-HLHZJIEZSA-N
Purity>=98.0% (HPLC)

保管条件

-20 C

技術属性

Monomer class
2'-O-methyl RNA CE phosphoramidite
Nucleobase
Hypoxanthine
Sugar modification
2'-O-Methyl
Base protection
Unprotected
Grade
N (Normal)
Packaging
50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 100 g; 200 g; Custom packaging on request
Water content
<=0.20% by Karl Fischer
Physical form
white/off-white to faint yellow powder; free from visible foreign matter
Stability
>=4 years

用途情報

  • 2'-OMe RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 2'-OMe sugar modification: cited 2'-O-methyl oligonucleotide literature discusses nuclease resistance and RNA affinity.
  • No base protection needed: the hypoxanthine base has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile 5'-DMT, removed each cycle).

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why does the 2'-OMe-inosine phosphoramidite have no base protecting group?

The hypoxanthine base of inosine has no reactive exocyclic amine, so it needs no base protection. The monomer carries the acid-labile 5'-O-DMT group, removed each cycle, and the 3'-phosphoramidite coupling group.

How does it differ from the 2'-O-TBDMS-inosine phosphoramidite?

This one has a 2'-O-methyl modification (a permanent methyl on the 2'-oxygen), whereas the 2'-O-TBDMS form protects the 2'-hydroxyl with a silyl group that is later removed. The 2'-O-TBDMS form is cataloged separately.

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