CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-O-MOE-Uridine CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65038CAS番号163759-97-5純度>=98%
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C42H53N4O10P
分子量
804.9
純度
>=98%

2'-O-MOE-Uridine CE Phosphoramidite is the 2'-O-methoxyethyl uridine building block for modified-RNA synthesis: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-uridine bearing a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65038 is identified by CAS 163759-97-5, molecular formula C42H53N4O10P, molecular weight 804.9, PubChem CID 129896826, and InChIKey ZLOKLUONKGURQI-UAQIPLLRSA-N.

Nucleoside phosphoramidites are the coupling monomers used in automated solid-phase oligonucleotide synthesis: the 3'-phosphoramidite couples to the growing chain and the acid-labile 5'-DMT is removed each cycle. Because uracil has no exocyclic amine, no base protecting group is required. In the cited structure and stability literature, 2'-O-MOE ribonucleosides/residues are discussed in RNA-affinity and nuclease-resistance studies and as flanking residues in gapmer antisense oligonucleotides.

別名

DMT-2'-O-MOE-rU phosphoramidite; 5'-O-DMT-2'-O-MOE-uridine 3'-CE phosphoramidite

同定情報と仕様

Catalog No.CH65038
CAS No.163759-97-5
Molecular FormulaC42H53N4O10P
Molecular Weight804.9
PubChem CID129896826
InChIKeyZLOKLUONKGURQI-UAQIPLLRSA-N
Purity>=98%

保管条件

-20 C

技術属性

Monomer class
2'-O-MOE RNA CE phosphoramidite
Nucleobase
Uracil
Sugar modification
2'-O-(2-Methoxyethyl) (MOE)
Base protection
Unprotected
Grade
N (Normal)
Packaging
250 mg; 500 mg; 1 g; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder
Stability
>=4 years

用途情報

  • 2'-MOE RNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • 2'-MOE sugar modification: cited structure and stability literature discusses 2'-O-MOE residues in RNA-affinity and nuclease-resistance studies and as gapmer flank residues.
  • No base protection needed: uracil has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile 5'-DMT, removed each cycle).

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why does the 2'-MOE-uridine phosphoramidite have no base protecting group?

Uracil has no reactive exocyclic amine, so it needs no base protection. The monomer carries the acid-labile 5'-O-DMT group, removed each cycle, and the 3'-phosphoramidite coupling group.

How does it relate to 5'-O-DMT-2'-O-MOE-uridine?

It is the phosphoramidite of that nucleoside: the 3'-hydroxyl has been converted to a 2-cyanoethyl N,N-diisopropyl phosphoramidite. The precursor is cataloged separately.

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