Oligonucleotide Synthesis, RNA Raw Materials & Modification

Morpholino C Subunit (PMO)

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65042CAS番号956139-21-2純度99.64%

製品画像はありません

製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C37H37ClN5O5P
分子量: 698.1
純度: 99.64%

Morpholino C Subunit is the cytosine building block for phosphorodiamidate morpholino oligomer (PMO) synthesis. It is a morpholine ring bearing a base-protected (benzoyl) cytosine, a trityl-protected morpholine nitrogen, and an activated phosphorodiamidochloridate coupling group. CH65042 is identified by CAS 956139-21-2, molecular formula C37H37ClN5O5P, molecular weight 698.1, PubChem CID 16662132, and InChIKey RCQVHNTXMQCQLT-AUIRFOQBSA-N.

PMOs are nonionic DNA analogs in which a morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate. This activated subunit provides the cytosine morpholino subunit identity for PMO assembly.

別名

PMO cytosine subunit; morpholino cytidine chlorophosphoramidate subunit

同定情報と仕様

Catalog No.	CH65042
CAS No.	956139-21-2
Molecular Formula	C37H37ClN5O5P
Molecular Weight	698.1
PubChem CID	16662132
InChIKey	RCQVHNTXMQCQLT-AUIRFOQBSA-N
Purity	99.64%

保管条件

-20 C

技術属性

Monomer class: PMO morpholino subunit
Nucleobase: Cytosine
Backbone scaffold: Morpholine
Activated group: Phosphorodiamidochloridate
Grade: N (Normal)
Packaging: 50 mg; 100 mg; 200 mg; 500 mg; 5 g; Custom packaging on request
Water content: <=0.5%
Physical form: white to off-white powder
Stability: stable under recommended storage conditions; avoid moisture

用途情報

PMO cytosine building block: provides the cytosine morpholino subunit identity for phosphorodiamidate morpholino oligomer (PMO) synthesis.
Morpholino backbone: the morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate, giving a nonionic oligomer.
Protected, activated subunit: the cytosine base is benzoyl-protected, the morpholine nitrogen is trityl-protected, and the phosphorodiamidochloridate is the reactive coupling group.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 16662132
PubChem · CID 16662132

よくある質問

What is a morpholino (PMO) subunit?

It is a building block for phosphorodiamidate morpholino oligomers (PMOs), nonionic DNA analogs in which a morpholine ring replaces the ribose and phosphorodiamidate linkages replace the phosphates. This product provides the cytosine morpholino subunit identity.

How is it protected and activated?

The cytosine base is benzoyl-protected, the morpholine nitrogen is trityl-protected, and the reactive phosphorodiamidochloridate group is the coupling handle for PMO chain extension.