Morpholino T Subunit (PMO)
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C31H34ClN4O5P
- 分子量
- 609.0
- 純度
- >=98.0% (HPLC)
Morpholino T Subunit is the thymine building block for phosphorodiamidate morpholino oligomer (PMO) synthesis. It is a morpholine ring bearing a thymine base, a trityl-protected morpholine nitrogen, and an activated phosphorodiamidochloridate coupling group. CH65044 is identified by CAS 956139-30-3, molecular formula C31H34ClN4O5P, molecular weight 609.0, PubChem CID 16662134, and InChIKey DIRYYUMNQFXZQD-ZFXAPSKHSA-N.
PMOs are nonionic DNA analogs in which a morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate. This activated subunit provides the thymine morpholino subunit identity for PMO assembly. Because thymine has no exocyclic amine, no base protecting group is required.
別名
PMO thymine subunit; morpholino thymidine chlorophosphoramidate subunit
同定情報と仕様
| Catalog No. | CH65044 |
| CAS No. | 956139-30-3 |
| Molecular Formula | C31H34ClN4O5P |
| Molecular Weight | 609.0 |
| PubChem CID | 16662134 |
| InChIKey | DIRYYUMNQFXZQD-ZFXAPSKHSA-N |
| Purity | >=98.0% (HPLC) |
保管条件
-20 C
技術属性
- Monomer class
- PMO morpholino subunit
- Nucleobase
- Thymine
- Backbone scaffold
- Morpholine
- Activated group
- Phosphorodiamidochloridate
- Grade
- N (Normal)
- Packaging
- 100 mg; 250 mg; 1 g; 5 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
用途情報
- PMO thymine building block: provides the thymine morpholino subunit identity for phosphorodiamidate morpholino oligomer (PMO) synthesis.
- Morpholino backbone: the morpholine ring replaces the ribose and a phosphorodiamidate linkage replaces the phosphate, giving a nonionic oligomer.
- Trityl-protected, activated subunit: the morpholine nitrogen is trityl-protected and the phosphorodiamidochloridate is the reactive coupling group; thymine needs no base protection.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 16662134
PubChem · CID 16662134
よくある質問
What is a morpholino (PMO) subunit?
It is a building block for phosphorodiamidate morpholino oligomers (PMOs), nonionic DNA analogs in which a morpholine ring replaces the ribose and phosphorodiamidate linkages replace the phosphates. This product provides the thymine morpholino subunit identity.
Why does the thymine subunit have no base protecting group?
Thymine has no reactive exocyclic amine, so it needs no base protection. The subunit carries a trityl-protected morpholine nitrogen and the reactive phosphorodiamidochloridate coupling group.
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