(S)-GNA-G(iBu) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C42H52N7O7P
- 分子量
- 797.9
- 純度
- >=99% (HPLC)
(S)-GNA-G(iBu) CE Phosphoramidite is the glycol nucleic acid (GNA) guanine building block for oligonucleotide synthesis: an (S)-propylene-glycol nucleoside bearing an N2-isobutyryl guanine, a DMT-protected hydroxyl, and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65057 is identified by CAS 182625-68-9, molecular formula C42H52N7O7P, molecular weight 797.9, PubChem CID 136859130, and InChIKey GOUPKQZMFOWLOW-AUNMUFMCSA-N.
GNA is described in the cited literature as a simplified nucleic acid with an acyclic propylene glycol phosphodiester backbone, and the cited (S)-GNA literature discusses heteroduplex formation with RNA. As a phosphoramidite, the reactive phosphoramidite couples to the growing chain, the acid-labile DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
別名
(S)-GNA-G(iBu) phosphoramidite; DMT-(S)-glycol-N2-isobutyrylguanine CE phosphoramidite
同定情報と仕様
| Catalog No. | CH65057 |
| CAS No. | 182625-68-9 |
| Molecular Formula | C42H52N7O7P |
| Molecular Weight | 797.9 |
| PubChem CID | 136859130 |
| InChIKey | GOUPKQZMFOWLOW-AUNMUFMCSA-N |
| Purity | >=99% (HPLC) |
保管条件
-20 C
技術属性
- Monomer class
- (S)-GNA CE phosphoramidite
- Nucleobase
- Guanine
- Backbone scaffold
- Glycol nucleic acid
- Base protection
- N2-isobutyryl
- Grade
- N (Normal)
- Packaging
- 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
- Stability
- stable under recommended storage conditions; avoid moisture
用途情報
- GNA coupling monomer: the (2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing GNA chain in solid-phase synthesis.
- Acyclic glycol backbone: GNA replaces the sugar-phosphate backbone with an acyclic propylene glycol phosphodiester backbone; the cited (S)-GNA literature discusses heteroduplex formation with RNA.
- DMT + N2-isobutyryl protection: the acid-labile DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 136859130
PubChem · CID 136859130
よくある質問
How does it differ from the (S)-GNA-A(Bz) amidite?
Both are (S)-GNA phosphoramidites, but this one has an N2-isobutyryl-protected guanine, whereas the (S)-GNA-A(Bz) amidite has an N6-benzoyl adenine. Each GNA base is cataloged separately.
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