UNA-A(Bz) CE Phosphoramidite
Oligonucleotide Synthesis, RNA Raw Materials & Modification
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Synthesis, RNA Raw Materials & Modification
- 分子式
- C54H58N7O9P
- 分子量
- 980.1
- 純度
- >=99% (HPLC)
UNA-A(Bz) CE Phosphoramidite is the unlocked nucleic acid (UNA) adenine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N6-benzoyl adenine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65059 is identified by CAS 1120329-52-3, molecular formula C54H58N7O9P, molecular weight 980.1, PubChem CID 138376031, and InChIKey DETQAICZNNZAEM-OWWCMFKUSA-N.
The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
別名
UNA-A(Bz) phosphoramidite; DMT-unlocked-N6-benzoyladenosine CE phosphoramidite
同定情報と仕様
| Catalog No. | CH65059 |
| CAS No. | 1120329-52-3 |
| Molecular Formula | C54H58N7O9P |
| Molecular Weight | 980.1 |
| PubChem CID | 138376031 |
| InChIKey | DETQAICZNNZAEM-OWWCMFKUSA-N |
| Purity | >=99% (HPLC) |
保管条件
-20 C
技術属性
- Monomer class
- UNA CE phosphoramidite
- Nucleobase
- Adenine
- Sugar topology
- C2'-C3' bond-opened ribose
- Base protection
- N6-benzoyl
- Grade
- N (Normal)
- Packaging
- 1 g; 5 g; 10 g; 50 g; Custom packaging on request
- Water content
- <=0.5%
- Physical form
- white to off-white powder
用途情報
- UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
- Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
- 5'-DMT + N6-benzoyl protection: the acid-labile 5'-DMT is removed each cycle, and the N6-benzoyl base group is removed at final deprotection.
関連技術資料
公開情報源
- Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
- Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
- Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
- Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
- PubChem化合物 138376031
PubChem · CID 138376031
よくある質問
What residue identity does this UNA amidite provide?
It provides the unlocked (UNA) adenine residue identity through its 3'-phosphoramidite coupling group, with 5'-DMT removed each cycle and N6-benzoyl removed at final deprotection.
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