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Oligonucleotide Synthesis, RNA Raw Materials & Modification

UNA-C(Ac) CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65060CAS番号1120329-56-7純度>=98.0% (HPLC)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C48H56N5O10P
分子量
894.0
純度
>=98.0% (HPLC)

UNA-C(Ac) CE Phosphoramidite is the unlocked nucleic acid (UNA) cytosine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N4-acetyl cytosine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65060 is identified by CAS 1120329-56-7, molecular formula C48H56N5O10P, molecular weight 894.0, PubChem CID 138376033, and InChIKey UMUWXRLDMCRCFS-GXOVKUNTSA-N.

The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.

別名

UNA-C(Ac) phosphoramidite; DMT-unlocked-N4-acetylcytidine CE phosphoramidite

同定情報と仕様

Catalog No.CH65060
CAS No.1120329-56-7
Molecular FormulaC48H56N5O10P
Molecular Weight894.0
PubChem CID138376033
InChIKeyUMUWXRLDMCRCFS-GXOVKUNTSA-N
Purity>=98.0% (HPLC)

保管条件

-20 C

技術属性

Monomer class
UNA CE phosphoramidite
Nucleobase
Cytosine
Sugar topology
C2'-C3' bond-opened ribose
Base protection
N4-acetyl
Grade
N (Normal)
Packaging
10 mg; 50 mg; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; 5 kg; 10 kg; 25 kg; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder
Stability
powder 3 years; in solvent 1 year

用途情報

  • UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
  • 5'-DMT + N4-acetyl protection: the acid-labile 5'-DMT is removed each cycle, and the N4-acetyl base group is removed at final deprotection.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from the UNA-A(Bz) amidite?

Both are UNA (unlocked) phosphoramidites, but this one has an N4-acetyl-protected cytosine, whereas the UNA-A(Bz) amidite has an N6-benzoyl adenine. Each UNA base is cataloged separately.

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