CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

UNA-G(iBu) CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65061CAS番号1120329-61-4純度>=98.0% (HPLC)
製品画像はありません

製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C51H60N7O10P
分子量
962.0
純度
>=98.0% (HPLC)

UNA-G(iBu) CE Phosphoramidite is the unlocked nucleic acid (UNA) guanine building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing an N2-isobutyryl guanine, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65061 is identified by CAS 1120329-61-4, molecular formula C51H60N7O10P, molecular weight 962.0, PubChem CID 138376032, and InChIKey PCZJDFIZVYBABW-WESQYFQMSA-N.

The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain, the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.

別名

UNA-G(iBu) phosphoramidite; DMT-unlocked-N2-isobutyrylguanosine CE phosphoramidite

同定情報と仕様

Catalog No.CH65061
CAS No.1120329-61-4
Molecular FormulaC51H60N7O10P
Molecular Weight962.0
PubChem CID138376032
InChIKeyPCZJDFIZVYBABW-WESQYFQMSA-N
Purity>=98.0% (HPLC)

保管条件

-20 C

技術属性

Monomer class
UNA CE phosphoramidite
Nucleobase
Guanine
Sugar topology
C2'-C3' bond-opened ribose
Base protection
N2-isobutyryl
Grade
N (Normal)
Packaging
10 mg; 50 mg; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder
Stability
powder 3 years; in solvent 1 year

用途情報

  • UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
  • 5'-DMT + N2-isobutyryl protection: the acid-labile 5'-DMT is removed each cycle, and the N2-isobutyryl base group is removed at final deprotection.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

How does it differ from the UNA-A(Bz) amidite?

Both are UNA (unlocked) phosphoramidites, but this one has an N2-isobutyryl-protected guanine, whereas the UNA-A(Bz) amidite has an N6-benzoyl adenine. Each UNA base is cataloged separately.

類似製品

2',3',5'-Tri-O-acetyl-D-adenosine

CAS番号
7387-57-7
分子式
C16H19N5O7
分子量
393.35

L-Threoninol

CAS番号
3228-51-1
分子式
C4H11NO2
分子量
105.14

Tetrabenzyl pyrophosphate

CAS番号
990-91-0
分子式
C28H28O7P2
分子量
538.47

2'-Deoxyadenosine Monohydrate

CAS番号
16373-93-6
分子式
C10H15N5O4
分子量
269.26

材料選択の支援が必要ですか？

CHEMOSは製品適合性、目標構造、ルート上の課題、分析要件、プロジェクト別供給ニーズを確認します。

プロジェクト支援を見る