CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

UNA-U CE Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65062CAS番号1120329-48-7純度99%
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C46H53N4O10P
分子量
852.9
純度
99%

UNA-U CE Phosphoramidite is the unlocked nucleic acid (UNA) uracil building block for oligonucleotide synthesis: an acyclic (C2'-C3' bond-opened) ribonucleoside bearing a uracil base, a 5'-O-(4,4'-dimethoxytrityl) group, and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite group. CH65062 is identified by CAS 1120329-48-7, molecular formula C46H53N4O10P, molecular weight 852.9, PubChem CID 100942372, and InChIKey MHRGEJFLFYZLJI-LZOZAVILSA-N.

The cited UNA literature discusses unlocked acyclic nucleic acid structures in relation to duplex characteristics. As a phosphoramidite, the 3'-phosphoramidite couples to the growing chain and the acid-labile 5'-DMT is removed each cycle. Because uracil has no exocyclic amine, no base protecting group is required.

別名

UNA-U phosphoramidite; DMT-unlocked-uridine CE phosphoramidite

同定情報と仕様

Catalog No.CH65062
CAS No.1120329-48-7
Molecular FormulaC46H53N4O10P
Molecular Weight852.9
PubChem CID100942372
InChIKeyMHRGEJFLFYZLJI-LZOZAVILSA-N
Purity99%

保管条件

-20 C

技術属性

Monomer class
UNA CE phosphoramidite
Nucleobase
Uracil
Sugar topology
C2'-C3' bond-opened ribose
Base protection
None required
Grade
N (Normal)
Packaging
100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 kg; 5 kg; 10 kg; 25 kg; Custom packaging on request
Water content
<=0.5%
Physical form
white to off-white powder

用途情報

  • UNA coupling monomer: the 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite is the reactive group that couples to the growing oligonucleotide chain in automated solid-phase synthesis.
  • Unlocked acyclic modification: the cited UNA literature discusses C2'-C3' bond-opened ribose structures in relation to oligonucleotide duplex characteristics.
  • No base protection needed: uracil has no exocyclic amine, so this monomer requires no base protecting group (only the acid-labile 5'-DMT, removed each cycle).

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Why does the UNA-U amidite have no base protecting group?

Uracil has no reactive exocyclic amine, so it needs no base protection. The monomer carries only the acid-labile 5'-O-DMT group (removed each cycle) and the reactive phosphoramidite coupling group.

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