CHEMOS
Oligonucleotide Conjugation & Delivery Ligands

5'-GalNAc C3 Phosphoramidite

Oligonucleotide Conjugation & Delivery Ligands

製品番号CH67005CAS番号2437303-51-8純度>98%
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製品概要

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製品ファミリー
Oligonucleotide Conjugation & Delivery Ligands
分子式
C62H88N5O17P
分子量
1206.4
純度
>98%

5'-GalNAc C3 Phosphoramidite is a conjugate building block for installing an N-acetylgalactosamine ("GalNAc") ligand on an oligonucleotide. Its C3-linker scaffold carries a trimethoxytrityl (TMT)-protected hydroxymethyl group and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite. Key identifiers include CAS 2437303-51-8, molecular formula C62H88N5O17P, and molecular weight 1206.4 (PubChem CID 170903051).

The phosphoramidite installs GalNAc at the oligonucleotide 5'-terminus. Glen Research identifies TMT, not DMT, as the protecting group for this product line and demonstrates consecutive GalNAc-amidite additions after detritylation. GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.

別名

5'-GalNAc-C3 phosphoramidite; N-acetylgalactosamine C3-linker amidite

同定情報と仕様

Catalog No.CH67005
CAS No.2437303-51-8
Molecular FormulaC62H88N5O17P
Molecular Weight1206.4
PubChem CID170903051
InChIKeyCBVYXTMIYQCOPE-KDYLSCEUSA-N
Purity>98%

保管条件

-20 +/- 5 C

技術属性

Ligand
N-Acetylgalactosamine (GalNAc)
Linker
C3
Coupling group
Phosphoramidite
Oligonucleotide position
5'-Terminal modification
Packaging
250 mg; 50 µmol; 100 µmol; Custom packaging on request
Physical form
white to light-yellow powder

用途情報

  • 5'-GalNAc conjugation: installs an N-acetylgalactosamine ligand on a C3 linker at the oligonucleotide 5'-terminus.
  • Consecutive GalNAc additions: the TMT-protected hydroxymethyl group supports another GalNAc-amidite addition after detritylation.
  • ASGPR ligand: GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.

関連技術資料

肝細胞標的デリバリー

GalNAc リガンド、オリゴコンジュゲーションハンドル、脂質コンジュゲート、肝臓指向デリバリー研究用リンカー。

GalNAc と脂質コンジュゲーションの比較

受容体指向多価 GalNAc と構造依存 脂質 コンジュゲーション を異なる戦略として比較します。

公開情報源

よくある質問

What does this GalNAc phosphoramidite do?

It installs an N-acetylgalactosamine (GalNAc) ligand on a C3 linker at the oligonucleotide 5'-terminus. The scaffold carries a trimethoxytrityl (TMT)-protected hydroxymethyl group, which can be detritylated before another GalNAc-amidite addition.

What does GalNAc bind?

GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.

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