GalNAc-L96-Succinate
Oligonucleotide Conjugation & Delivery Ligands
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Conjugation & Delivery Ligands
- 分子式
- C121H179N11O45
- 分子量
- 2507.8
- 純度
- >=99%
GalNAc-L96-Succinate is a conjugate support-loading precursor for oligonucleotide synthesis: the free-acid form of a triantennary (trivalent) N-acetylgalactosamine ("GalNAc", L96) cluster joined to a succinate half-ester. Key identifiers include CAS 1159408-61-3, molecular formula C121H179N11O45, and molecular weight 2507.8 (PubChem CID 162394059). The triethylammonium salt of the same cluster is catalogued as CH67002.
Unlike a phosphoramidite, this reagent carries a 3'-O-succinate half-ester rather than a coupling group. The succinate is the conventional linker for attaching a 3'-terminal unit — here the GalNAc cluster — to an amino-functionalized solid support, so the oligonucleotide is then assembled carrying the GalNAc ligand at its 3'-end. The succinyl linkage is base-cleavable and is broken during deprotection to release the finished conjugate. Triantennary GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
別名
triantennary GalNAc (L96) succinate (free acid); trivalent N-acetylgalactosamine cluster support-loading succinate
同定情報と仕様
| Catalog No. | CH67007 |
| CAS No. | 1159408-61-3 |
| Molecular Formula | C121H179N11O45 (free acid) |
| Molecular Weight | 2507.8 |
| PubChem CID | 162394059 |
| InChIKey | XKEQVRGRWUKTIZ-OLTBZPFJSA-N |
| Purity | >=99% |
保管条件
-20 C
技術属性
- Ligand format
- Triantennary GalNAc cluster
- Linker scaffold
- L96
- Functional terminus
- 3'-O-Succinate
- Material form
- Free acid
- Packaging
- 500 mg; 1 g; 2 g; 10 g; 100 g; 1 kg; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
用途情報
- GalNAc-L96-Succinate reference: use this GalNAc support-linker building block record for oligonucleotide conjugation and delivery-ligand catalog work.
- Identifier cross-check: compare CAS 1159408-61-3, PubChem CID 162394059, formula C121H179N11O45 (free acid), MW 2507.8, and the listed InChIKey for catalog identity matching.
- Inquiry preparation: include catalog number CH67007, the product name, and the identity-matching identifiers when preparing a CHEMOS product inquiry.
関連技術資料
公開情報源
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem化合物 162394059
PubChem · CID 162394059
よくある質問
How does this differ from GalNAc-L96-Succinate, TEA salt (CH67002)?
This is the free-acid form of the same triantennary GalNAc cluster succinate; CH67002 is the triethylammonium (TEA) salt. Both serve the same role as a 3'-GalNAc support-loading precursor.
What is a triantennary GalNAc cluster, and what does it bind?
It is a trivalent presentation of N-acetylgalactosamine (three GalNAc sugars on a branched scaffold). Triantennary GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
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