Tri-GalNAc(OAc)3 (TFA salt)
Oligonucleotide Conjugation & Delivery Ligands
製品概要
クイックビュー
- 製品ファミリー
- Oligonucleotide Conjugation & Delivery Ligands
- 分子式
- C81H129F3N10O38
- 分子量
- 1907.9
- 純度
- >99.00%
Tri-GalNAc(OAc)3 (TFA salt) is a peracetylated triantennary (trivalent) N-acetylgalactosamine ("GalNAc") cluster — three acetyl-protected GalNAc units on a branched scaffold — supplied as its trifluoroacetate (TFA) salt. Key identifiers include CAS 1159408-65-7, molecular formula C81H129F3N10O38, and molecular weight 1907.9 (PubChem CID 162394061).
It is a protected GalNAc-cluster intermediate for oligonucleotide conjugation chemistry: the acetyl groups protect the sugar hydroxyls during synthesis and are removed by deacetylation to give the finished ligand. Triantennary GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
別名
peracetylated triantennary GalNAc cluster, TFA salt; acetyl-protected trivalent N-acetylgalactosamine cluster
同定情報と仕様
| Catalog No. | CH67011 |
| CAS No. | 1159408-65-7 |
| Molecular Formula | C81H129F3N10O38 (trifluoroacetate salt) |
| Molecular Weight | 1907.9 |
| PubChem CID | 162394061 |
| InChIKey | ZQQFLUVDYMPTBZ-QBHSIBJISA-N |
| Purity | >99.00% |
保管条件
-20 C
技術属性
- Ligand format
- Triantennary GalNAc cluster
- Protection state
- Peracetylated
- Counterion form
- Trifluoroacetate salt
- Research role
- Oligonucleotide-conjugation intermediate
- Packaging
- 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g; Custom packaging on request
- Physical form
- solid
- Stability
- >=4 years
用途情報
- Protected triantennary GalNAc cluster: three acetyl-protected GalNAc units on a branched scaffold, used as an intermediate in conjugation chemistry.
- Acetyl-protected hydroxyls: the sugar hydroxyls are acetyl-protected during synthesis and removed by deacetylation to give the finished ligand.
- ASGPR ligand: triantennary GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
関連技術資料
公開情報源
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency in mice
Nucleic Acids Research, 2014
Product-family technical context
- Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits RNAi-mediated gene silencing
Journal of the American Chemical Society, 2014
Product-family technical context
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
ACS Chemical Biology, 2015
Product-family technical context
- Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands
Journal of Pharmacology and Experimental Therapeutics, 2016
Product-family technical context
- PubChem化合物 162394061
PubChem · CID 162394061
よくある質問
What does '(OAc)3' and 'TFA' mean here?
(OAc)3 indicates the GalNAc sugar hydroxyls are acetyl-protected (acetate esters), and TFA means the compound is supplied as its trifluoroacetate salt. The acetyl groups are removed by deacetylation to reveal the finished GalNAc ligand.
What is a triantennary GalNAc cluster, and what does it bind?
It is a trivalent presentation of N-acetylgalactosamine (three GalNAc sugars on a branched scaffold). Triantennary GalNAc binds the asialoglycoprotein receptor (ASGPR), a lectin on the surface of hepatocytes.
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