Oligonucleotide Synthesis, RNA Raw Materials & Modification

Spacer-18 (Hexaethylene Glycol) Phosphoramidite

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65100CAS番号125607-09-2純度99%

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製品概要

クイックビュー

製品ファミリー: Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式: C42H61N2O10P
分子量: 784.9
純度: 99%

Spacer-18 (Hexaethylene Glycol) Phosphoramidite is a non-nucleotide (abasic) spacer building block: a hexaethylene glycol chain carrying a 5'-O-(4,4'-dimethoxytrityl) group and a 3'-O-(2-cyanoethyl N,N-diisopropyl)phosphoramidite. Its PubChem-backed identity includes CAS 125607-09-2, molecular formula C42H61N2O10P, molecular weight 784.9, and PubChem CID 22904875.

Coupling inserts a long, flexible, polar non-nucleotide ethylene-glycol spacer into the oligonucleotide backbone in place of nucleotides. The cited hexaethylene glycol literature describes this chain type joining two complementary segments into a hairpin. The spacer couples through its 3'-phosphoramidite, and its 5'-DMT is removed each cycle so chain assembly continues.

別名

Spacer 18; hexaethylene glycol spacer phosphoramidite; DMT-O-(hexaethylene glycol)-3'-CE phosphoramidite

同定情報と仕様

Catalog No.	CH65100
CAS No.	125607-09-2
Molecular Formula	C42H61N2O10P
Molecular Weight	784.9
PubChem CID	22904875
InChIKey	ZTCKUVQHKIMCLI-UHFFFAOYSA-N
Purity	99%

保管条件

-20 C in dark; desiccate; protect from prolonged light

技術属性

Reagent class: Non-nucleotide spacer phosphoramidite
Spacer type: Hexaethylene glycol
Ethylene glycol units: 6
End protection: 5'-O-DMT
Grade: N (Normal)
Packaging: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 kg; 10 kg; 100 µmol; Custom packaging on request
Water content: <=0.5%
Physical form: colorless/yellowish oil
Stability: 12 months after receipt under stated storage

用途情報

Long flexible ethylene-glycol spacer: introduces a long, polar hexaethylene glycol abasic spacer into the oligonucleotide backbone in place of nucleotides.
Hairpin loop: a hexaethylene glycol chain can join two complementary segments into a hairpin loop.
Chain-compatible: couples through a 3'-phosphoramidite and carries a 5'-DMT that is removed each cycle, so synthesis can continue past the spacer.

公開情報源

Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
Journal of Organic Chemistry, 2021
Product-family technical context
Solid-phase supports for oligonucleotide synthesis
Current Protocols in Nucleic Acid Chemistry, 2013
Product-family technical context
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
Tetrahedron Letters, 1981
Product-family technical context
Synthesis of deoxyoligonucleotides on a polymer support
Journal of the American Chemical Society, 1981
Product-family technical context
PubChem化合物 22904875
PubChem · CID 22904875

よくある質問

What is the Spacer-18 (hexaethylene glycol) phosphoramidite?

It is a non-nucleotide (abasic) spacer built on a hexaethylene glycol chain. Coupling inserts a long, flexible, polar ethylene-glycol spacer into the oligonucleotide backbone in place of nucleotides.