CHEMOS
Oligonucleotide Conjugation & Delivery Ligands

MMT-C6-Amine-Linker Phosphoramidite

Oligonucleotide Conjugation & Delivery Ligands

製品番号CH65104CAS番号114616-27-2純度>=99.5% (HPLC)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Conjugation & Delivery Ligands
分子式
C35H48N3O3P
分子量
589.7
純度
>=99.5% (HPLC)

MMT-C6-Amine-Linker Phosphoramidite is a non-nucleoside modifier for adding a reactive amino group to an oligonucleotide: a six-carbon (hexyl) linker carrying a monomethoxytrityl (MMT)-protected primary amine at one end and a (2-cyanoethyl N,N-diisopropyl)phosphoramidite at the other. Its PubChem-backed identity includes CAS 114616-27-2, molecular formula C35H48N3O3P, molecular weight 589.7, and PubChem CID 9873234.

Coupling attaches an aminohexyl arm to the oligonucleotide (typically the 5'-terminus). The acid-labile MMT group protects the amine during synthesis and is removed afterward to reveal a free primary amine on a C6 spacer. The cited amino-modifier literature describes aliphatic amino groups reacting with electrophiles, allowing dyes, biotin, or other chemical species to be attached to oligonucleotides.

別名

5'-Amino-Modifier C6; 6-(MMT-amino)hexyl-(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidite

同定情報と仕様

Catalog No.CH65104
CAS No.114616-27-2
Molecular FormulaC35H48N3O3P
Molecular Weight589.7
PubChem CID9873234
InChIKeyYBANXOPIYSVPMH-UHFFFAOYSA-N
Purity>=99.5% (HPLC)

保管条件

-20 C

技術属性

Modifier type
Non-nucleoside amino-modifier phosphoramidite
Spacer
C6 (hexyl)
Protecting group
MMT (monomethoxytrityl), acid-labile
Exposed handle
Primary amine after MMT removal
Grade
N (Normal)
Packaging
10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 2 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 kg; 5 kg; 100 µmol; Custom packaging on request
Water content
<=0.5%
Physical form
colorless oily liquid
Stability
Acetonitrile solution: use within 24 hours

用途情報

  • Amino conjugation handle: provides a primary amine on a six-carbon spacer at the oligonucleotide terminus.
  • Electrophile-reactive amine: the cited literature describes aliphatic amino groups reacting with electrophiles to attach dyes, biotin, or other species.
  • MMT-protected during synthesis: the acid-labile MMT group masks the amine during assembly and is removed to expose it afterward.

関連技術資料

肝細胞標的デリバリー

GalNAc リガンド、オリゴコンジュゲーションハンドル、脂質コンジュゲート、肝臓指向デリバリー研究用リンカー。

GalNAc と脂質コンジュゲーションの比較

受容体指向多価 GalNAc と構造依存 脂質 コンジュゲーション を異なる戦略として比較します。

公開情報源

よくある質問

What does this amino-linker do?

It provides a primary amine on a six-carbon spacer at an oligonucleotide terminus. After the MMT protecting group is removed, the amine can react with electrophiles to attach dyes, biotin, or other conjugates.

Why is the amine MMT-protected?

The monomethoxytrityl (MMT) group masks the reactive amine during solid-phase synthesis. It is acid-labile and removed afterward to reveal the free primary amine for conjugation.

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