CHEMOS
Oligonucleotide Synthesis, RNA Raw Materials & Modification

2'-MOE-A (Bz) 3'-Succinate, Triethylammonium Salt

Oligonucleotide Synthesis, RNA Raw Materials & Modification

製品番号CH65119CAS番号444814-78-2純度>=98.0% (HPLC)
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製品概要

クイックビュー

製品ファミリー
Oligonucleotide Synthesis, RNA Raw Materials & Modification
分子式
C45H45N5O11
分子量
831.9
純度
>=98.0% (HPLC)

2'-MOE-A (Bz) 3'-Succinate, Triethylammonium Salt is a support-loading precursor for oligonucleotide synthesis: 5'-O-(4,4'-dimethoxytrityl)-N6-benzoyl-2'-O-(2-methoxyethyl)adenosine 3'-O-succinate, listed as its triethylammonium salt. Its PubChem-backed succinate identity includes CAS 444814-78-2, molecular formula C45H45N5O11, molecular weight 831.9, and PubChem CID 168447036.

Unlike a phosphoramidite, this reagent carries a 3'-O-succinate half-ester rather than a coupling group. The succinate is the conventional linker for attaching the 3'-terminal 2'-MOE nucleoside to an amino-functionalized solid support (such as controlled-pore glass), so that chain assembly starts from this residue. The succinyl linkage is base-cleavable and is broken during deprotection to release the finished oligonucleotide; cited 2'-MOE literature provides the RNA-binding and nuclease-stability context, while 5'-DMT protects the 5'-hydroxyl and N6-benzoyl protects the adenine amine.

別名

DMT-2'-MOE-A(Bz)-3'-succinate TEA salt; 5'-O-DMT-N6-Bz-2'-O-(2-methoxyethyl)adenosine-3'-O-succinyl triethylammonium salt

同定情報と仕様

Catalog No.CH65119
CAS No.444814-78-2
Molecular FormulaC45H45N5O11 (succinate)
Molecular Weight831.9
PubChem CID168447036
InChIKeyQDFWOVDXCRSHLI-NPHJKCPPSA-N
Purity>=98.0% (HPLC)

保管条件

-20 C; tightly closed; protected from humidity

技術属性

Reagent class
3'-O-succinate support-loading precursor
Terminal residue
2'-O-MOE-A(Bz)
Support linker
Succinate half-ester
Salt form
Triethylammonium
Packaging
Custom packaging on request
Physical form
white, off-white to light yellow powder

用途情報

  • 3'-terminal support loading: the 3'-O-succinate couples to an amino-functionalized solid support to immobilize the 3'-terminal 2'-MOE-A(Bz) residue.
  • Base-cleavable linker: the succinyl ester is cleaved during deprotection, releasing the finished oligonucleotide from the support.
  • 2'-O-MOE modification: cited 2'-MOE literature provides RNA-binding and nuclease-stability context for the 2'-O-(2-methoxyethyl) group; 5'-DMT protects the 5'-hydroxyl and N6-benzoyl protects the adenine amine.

関連技術資料

オリゴヌクレオチド修飾

ASO、siRNA、guide RNA、aptamer、研究用オリゴの糖、塩基、骨格、末端、コンジュゲーション修飾。

オリゴヌクレオチド合成

修飾モノマー、担体、硫化試薬、キャップ 類似体、関連するオリゴ合成入力物の支援。

公開情報源

よくある質問

Is this a phosphoramidite?

No. It is a 2'-MOE nucleoside 3'-O-succinate (a support-loading precursor), not a phosphoramidite. Its 3'-succinate half-ester attaches the 3'-terminal 2'-MOE residue to a solid support before chain assembly begins.

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